Bureau of Hepatitis, HIV, and STI, New York City Department of Health and Mental Hygiene, Queens, New York, USA.
Multinational Mpox Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis. 2024 Nov 15;230(5):1102-1109. doi: 10.1093/infdis/jiae181.
The extent to which infections may have been undetected in an epicenter of the 2022 mpox outbreak is unknown.
A serosurvey (July and August 2022) assessed the seroprevalence and correlates of mpox infection among a diverse sample of asymptomatic patients with no prior mpox diagnoses and no known histories of smallpox or mpox vaccination. We present seropositivity stratified by participant characteristics collected via survey.
Two-thirds of 419 participants were cismen (281 of 419), of whom 59.1% (166 of 281) reported sex with men (MSM). The sample also included 109 ciswomen and 28 transgender/gender nonconforming/nonbinary individuals. Overall seroprevalence was 6.4% (95% confidence interval [CI], 4.1%-8.8%); 3.7% among ciswomen (95% CI, 1.0%-9.1%), 7.0% among cismen with only ciswomen partners (95% CI, 2.0%-11.9%), and 7.8% among MSM (95% CI, 3.7%-11.9%). There was little variation in seroprevalence by race/ethnicity, age group, HIV status, or number of recent sex partners. No participants who reported close contact with mpox cases were seropositive. Among participants without recent mpox-like symptoms, 6.3% were seropositive (95% CI, 3.6%-9.0%).
Approximately 1 in 15 vaccine-naive people in our study had antibodies to mpox during the height of the NYC outbreak, indicating the presence of asymptomatic infections that could contribute to ongoing transmission.
在 2022 年猴痘疫情的中心，有多少感染可能未被发现尚不清楚。
一项血清学调查（2022 年 7 月和 8 月）评估了无症状患者中猴痘感染的血清流行率及其相关因素，这些患者没有先前的猴痘诊断，也没有天花或猴痘疫苗接种的已知病史。我们根据通过调查收集的参与者特征，对血清阳性率进行分层。
419 名参与者中有三分之二为男性（281 名），其中 59.1%（166 名）报告有男男性行为。该样本还包括 109 名女性和 28 名跨性别/性别不一致/非二进制个体。总血清阳性率为 6.4%（95%置信区间[CI]，4.1%-8.8%）；女性为 3.7%（95% CI，1.0%-9.1%），仅有女性性伴侣的男性为 7.0%（95% CI，2.0%-11.9%），男男性行为者为 7.8%（95% CI，3.7%-11.9%）。血清阳性率在种族/民族、年龄组、艾滋病毒状况或最近性伴侣数量方面差异不大。没有报告与猴痘病例密切接触的参与者呈血清阳性。在没有近期类似猴痘症状的参与者中，有 6.3%呈血清阳性（95% CI，3.6%-9.0%）。
在我们的研究中，大约每 15 名未接种疫苗的人群中就有 1 人在纽约市疫情高峰期时对猴痘有抗体，表明存在无症状感染，这可能导致持续传播。
