Chen Lu, Yang Wenqian, Yang Fei, Xu Tingwan, Yu Yanying, Wu Qian, Han Yanbing
First Department of Neurology, First Affiliated Hospital, Kunming Medical University, 295 Xi Chang Road, Kunming, Yunnan 650032, PR China.
Heliyon. 2024 Apr 27;10(9):e29950. doi: 10.1016/j.heliyon.2024.e29950. eCollection 2024 May 15.
Epilepsy is a chronic, relapsing neurological disorder, and current treatments focus primarily on neurons, yet one-third of patients still develop drug-resistant epilepsy. Therefore, there is an urgent need to explore new therapeutic targets. Interestingly, astrocytes can transfer their healthy mitochondria into neighboring neurons, thus preventing neuronal damage. Astrocyte mitochondria have been shown to have a therapeutic role in stroke and neurodegenerative diseases. However, their therapeutic effect in epilepsy and its related mechanisms have been less studied. In this review, we mainly summarize the regulatory role of astrocyte mitochondria in glutamate, calcium ion, and adenosine triphosphate (ATP) homeostasis and outline the protective role of astrocyte mitochondria in nervous system diseases, revealing a new target for epilepsy treatment.
癫痫是一种慢性复发性神经系统疾病，目前的治疗主要集中在神经元上，但仍有三分之一的患者会发展为药物难治性癫痫。因此，迫切需要探索新的治疗靶点。有趣的是，星形胶质细胞可以将其健康的线粒体转移到邻近的神经元中，从而防止神经元损伤。星形胶质细胞线粒体已被证明在中风和神经退行性疾病中具有治疗作用。然而，它们在癫痫中的治疗作用及其相关机制的研究较少。在这篇综述中，我们主要总结了星形胶质细胞线粒体在谷氨酸、钙离子和三磷酸腺苷（ATP）稳态中的调节作用，并概述了星形胶质细胞线粒体在神经系统疾病中的保护作用，揭示了癫痫治疗的新靶点。
