通过各种佐剂增强流感嗜血杆菌核糖体制剂的免疫原活性。

Enhancement of immunogenic activity of ribosomal preparations from Haemophilus influenzae by various adjuvants.

作者信息

Cabrera-Contreras R, Plescia O, Solotorovsky M, Lynn M

出版信息

Vaccine. 1985 Jun;3(2):103-8. doi: 10.1016/0264-410x(85)90057-x.

Abstract

Ribosomes from Haemophilus influenzae type b have been reported to have immunoprotective activity in animals that can be enhanced by adjuvants. In this report we evaluated the adjuvant activity of several compounds in conjunction with ribosomes from the b and c serotypes of H. influenzae. Alhydrogel, saponin, and DPT were found to significantly enhance the immunoprotective response in mice, equalling or exceeding the activity of Freund's incomplete adjuvant. All of these adjuvants also enhanced significantly the IgM response of mice to sheep red blood cells. Ribosomes were also found to enhance this response. Among the compounds failing to provide adjuvant activity for ribosomes were poly(A:U), muramyl dipeptide, mycobacterial extract, dimethylglycine, methylated bovine serum albumin, sodium diethylthiocarbamate, and cetyltrimethylammonium bromide.

摘要

据报道，b型流感嗜血杆菌的核糖体在动物体内具有免疫保护活性，佐剂可增强这种活性。在本报告中，我们评估了几种化合物与b型和c型流感嗜血杆菌核糖体联合使用时的佐剂活性。发现氢氧化铝凝胶、皂苷和白百破疫苗能显著增强小鼠的免疫保护反应，其活性等同于或超过弗氏不完全佐剂。所有这些佐剂还显著增强了小鼠对绵羊红细胞的IgM反应。核糖体也能增强这种反应。未能为核糖体提供佐剂活性的化合物包括聚（A:U）、胞壁酰二肽、分枝杆菌提取物、二甲基甘氨酸、甲基化牛血清白蛋白、二乙氨基二硫代甲酸钠和十六烷基三甲基溴化铵。