人血清和仓鼠血清中新冠病毒变异株特异性中和抗体的直接比较。
Direct comparison of SARS-CoV-2 variant specific neutralizing antibodies in human and hamster sera.
作者信息
Rössler Annika, Netzl Antonia, Knabl Ludwig, Wilks Samuel H, Mühlemann Barbara, Türeli Sina, Mykytyn Anna, von Laer Dorothee, Haagmans Bart L, Smith Derek J, Kimpel Janine
机构信息
Institute of Virology, Department of Hygiene, Microbiology and Public Health, Medical University of Innsbruck, Peter-Mayr-Str. 4b, 6020, Innsbruck, Austria.
Center for Virology and Vaccine Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA.
出版信息
NPJ Vaccines. 2024 May 18;9(1):85. doi: 10.1038/s41541-024-00888-y.
Antigenic characterization of newly emerging SARS-CoV-2 variants is important to assess their immune escape and judge the need for future vaccine updates. To bridge data obtained from animal sera with human sera, we analyzed neutralizing antibody titers in human and hamster single infection sera in a highly controlled setting using the same authentic virus neutralization assay performed in one laboratory. Using a Bayesian framework, we found that titer fold changes in hamster sera corresponded well to human sera and that hamster sera generally exhibited higher reactivity.
对新出现的严重急性呼吸综合征冠状病毒2（SARS-CoV-2）变体进行抗原特征分析，对于评估其免疫逃逸情况以及判断未来疫苗更新的必要性至关重要。为了将从动物血清和人类血清中获得的数据联系起来，我们在高度受控的环境中，使用在同一个实验室进行的相同的真实病毒中和试验，分析了人类和仓鼠单次感染血清中的中和抗体滴度。通过贝叶斯框架，我们发现仓鼠血清中的滴度变化倍数与人类血清高度吻合，并且仓鼠血清通常表现出更高的反应性。
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