从叶子和树枝中分离得到的化学成分及其激活潜伏 HIV 活性的作用。
Chemical constituents from the leaves and branches of with their activation of latent HIV activities.
机构信息
Key Laboratory of Chemical Biology and Molecular Engineering Ministry of Education, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China.
Shanxi Key Laboratory of Active Constituents Research and Utilization of TCM, Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006, China.
出版信息
J Asian Nat Prod Res. 2024 Oct;26(10):1239-1246. doi: 10.1080/10286020.2024.2355479. Epub 2024 May 23.
A new compound, named coniferin B (), and fourteen known compounds were purified and identified from the leaves and branches of Meisn. Their chemical structures were elucidated through analyzing spectroscopic and HRESIMS data. Compounds , , , -, and were isolated from this plant for the first time. All compounds were assayed for cytotoxicity and activation of latent HIV activity on NH2 cells. The results showed that all compounds did not produce cytotoxicity at 10.0 μM and compounds , - showed weak activating activity with activation folds of 4.88, 7.14, 5.3, and 6.97, respectively.
从梅氏落叶松的枝叶中分离得到一个新的化合物，命名为 coniferin B ()，并鉴定了 14 个已知化合物。通过分析光谱和 HRESIMS 数据阐明了它们的化学结构。化合物 、 、 、 - 和 首次从该植物中分离得到。所有化合物均进行了 NH2 细胞的细胞毒性和潜伏 HIV 活性激活测试。结果表明，所有化合物在 10.0 μM 时均无细胞毒性，化合物 、 - 表现出较弱的激活活性，激活倍数分别为 4.88、7.14、5.3 和 6.97。
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