Pelton B K, Harvey A R, Denman A M
Clin Exp Immunol. 1985 Dec;62(3):657-61.
Sixteen patients with rheumatoid arthritis were systemically immunized with influenza virus vaccine and in vitro anti-influenza antibody responses by blood lymphocytes and lymphocytes isolated from synovectomy specimens were measured after in vitro challenge with this influenza antigen. Synovial lymphocytes from eight of these patients produced anti-viral antibody, thereby indicating that infiltrating lymphocytes participate in a systemic anti-viral immune response.
16名类风湿性关节炎患者接受了流感病毒疫苗的全身免疫,并在体外使用该流感抗原进行刺激后,检测了血液淋巴细胞和从滑膜切除标本中分离出的淋巴细胞的体外抗流感抗体反应。其中8名患者的滑膜淋巴细胞产生了抗病毒抗体,这表明浸润淋巴细胞参与了全身抗病毒免疫反应。