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类风湿性滑膜参与全身抗病毒免疫反应。

The rheumatoid synovial membrane participates in systemic anti-viral immune responses.

作者信息

Pelton B K, Harvey A R, Denman A M

出版信息

Clin Exp Immunol. 1985 Dec;62(3):657-61.

PMID:3878754
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577495/
Abstract

Sixteen patients with rheumatoid arthritis were systemically immunized with influenza virus vaccine and in vitro anti-influenza antibody responses by blood lymphocytes and lymphocytes isolated from synovectomy specimens were measured after in vitro challenge with this influenza antigen. Synovial lymphocytes from eight of these patients produced anti-viral antibody, thereby indicating that infiltrating lymphocytes participate in a systemic anti-viral immune response.

摘要

16名类风湿性关节炎患者接受了流感病毒疫苗的全身免疫，并在体外使用该流感抗原进行刺激后，检测了血液淋巴细胞和从滑膜切除标本中分离出的淋巴细胞的体外抗流感抗体反应。其中8名患者的滑膜淋巴细胞产生了抗病毒抗体，这表明浸润淋巴细胞参与了全身抗病毒免疫反应。

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本文引用的文献

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Quantitation of cells secreting rheumatoid factor of IgG, IgA, and IgM class after elution from rheumatoid synovial tissue.从类风湿性滑膜组织洗脱后，对分泌IgG、IgA和IgM类类风湿因子的细胞进行定量分析。
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J Immunol. 1969 Feb;102(2):355-69.
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Clin Exp Immunol. 1972 Sep;12(1):55-70.
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In vitro synthesis of immunoglobulin by rheumatoid synovial membrane.类风湿性滑膜在体外合成免疫球蛋白。
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Specific in vitro antibody response to influenza virus by human blood lymphocytes.
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