Zoulek G, Bürger P, Deinhardt F
Bull World Health Organ. 1985;63(5):935-9.
The use of blood spotted on filter-paper is a cheap and convenient method for collecting, storing and transporting samples for analysis of markers of hepatitis virus B. Vaccine against viral hepatitis B is now available but is expensive, and, in order to make the best use of it, large-scale screening programmes need to be carried out in endemic areas prior to immunization campaigns. The sensitivity of the filter-paper method was compared with that of the analysis of whole serum, and the epidemiological data produced by the two methods were analysed. It was found that analysis of eluates of blood spotted on filter-paper cannot be recommended if accurate results are wanted, since large numbers of seropositive persons are likely to be missed; however, it may be a suitable method for detecting HBsAg-carriers and most anti-HBs-positive individuals prior to an immunization campaign.
使用滤纸上的血斑是一种廉价且便捷的方法，用于收集、储存和运输样本，以分析乙型肝炎病毒标志物。目前已有乙型病毒性肝炎疫苗，但价格昂贵。为了充分利用该疫苗，在免疫接种活动之前，需要在流行地区开展大规模筛查项目。将滤纸片血斑分析法与全血清分析法的灵敏度进行了比较，并对两种方法产生的流行病学数据进行了分析。结果发现，如果需要准确结果，不建议采用滤纸片血斑洗脱液分析法，因为可能会遗漏大量血清反应阳性者；然而，它可能是在免疫接种活动之前检测HBsAg携带者和大多数抗-HBs阳性个体的合适方法。
