Cui Chendi, Timbrook Tristan T, Polacek Cate, Heins Zoe, Rosenthal Ning A
PINC, AI Applied Sciences, Premier Inc., Charlotte, NC, United States.
Global Medical Affairs, bioMérieux, Inc., Salt Lake City, UT, United States.
Front Med (Lausanne). 2024 May 16;11:1325236. doi: 10.3389/fmed.2024.1325236. eCollection 2024.
Acute respiratory infections (ARIs) represent a significant public health concern in the U.S. This study aimed to describe the disease burden of ARIs and identify U.S. populations at high risk of developing complications.
This scoping review searched PubMed and EBSCO databases to analyze U.S. studies from 2013 to 2022, focusing on disease burden, complications, and high-risk populations associated with ARIs.
The study included 60 studies and showed that ARI is associated with a significant disease burden and healthcare resource utilization (HRU). In 2019, respiratory infection and tuberculosis caused 339,703 cases per 100,000 people, with most cases being upper respiratory infections and most deaths being lower respiratory infections. ARI is responsible for millions of outpatient visits, especially for influenza and pneumococcal pneumonia, and indirect costs of billions of dollars. ARI is caused by multiple pathogens and poses a significant burden on hospitalizations and outpatient visits. Risk factors for HRU associated with ARI include age, chronic conditions, and socioeconomic factors.
The review underscores the substantial disease burden of ARIs and the influence of age, chronic conditions, and socioeconomic status on developing complications. It highlights the necessity for targeted strategies for high-risk populations and effective pathogen detection to prevent severe complications and reduce HRU.
急性呼吸道感染（ARIs）是美国一个重大的公共卫生问题。本研究旨在描述ARIs的疾病负担，并确定有发生并发症高风险的美国人群。
本范围综述检索了PubMed和EBSCO数据库，以分析2013年至2022年的美国研究，重点关注与ARIs相关的疾病负担、并发症和高风险人群。
该研究纳入了60项研究，结果显示ARI与重大的疾病负担和医疗资源利用（HRU）相关。2019年，呼吸道感染和结核病每10万人导致339,703例病例，其中大多数病例为上呼吸道感染，大多数死亡病例为下呼吸道感染。ARI导致数百万次门诊就诊，尤其是流感和肺炎球菌肺炎，以及数十亿美元的间接成本。ARI由多种病原体引起，给住院和门诊就诊带来了重大负担。与ARI相关的HRU风险因素包括年龄、慢性病和社会经济因素。
该综述强调了ARIs的重大疾病负担，以及年龄、慢性病和社会经济状况对发生并发症的影响。它强调了针对高风险人群制定有针对性策略以及进行有效病原体检测以预防严重并发症和降低HRU的必要性。
