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Pharmacological effects and mechanisms of bee venom and its main components: Recent progress and perspective.蜂毒及其主要成分的药理作用和机制：最新进展与展望
Front Pharmacol. 2022 Sep 27;13:1001553. doi: 10.3389/fphar.2022.1001553. eCollection 2022.
2
Detoxification of Bee Venom Increases Its Anti-inflammatory Activity and Decreases Its Cytotoxicity and Allergenic Activity.蜂毒液的解毒作用提高了其抗炎活性，降低了其细胞毒性和变应原活性。
Appl Biochem Biotechnol. 2021 Dec;193(12):4068-4082. doi: 10.1007/s12010-021-03653-2. Epub 2021 Sep 20.
3
Antioxidant Activity in Bee Products: A Review.蜂产品中的抗氧化活性：综述
Antioxidants (Basel). 2021 Jan 7;10(1):71. doi: 10.3390/antiox10010071.
4
Investigation of anti-inflammatory effects of bee venom in experimentally induced adjuvant arthritis.蜂毒对实验性诱导佐剂性关节炎抗炎作用的研究。
Reumatologia. 2020;58(5):265-271. doi: 10.5114/reum.2020.99764. Epub 2020 Oct 15.
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Bee Venom: An Updating Review of Its Bioactive Molecules and Its Health Applications.蜂毒：生物活性分子及其健康应用的最新综述。
Nutrients. 2020 Oct 31;12(11):3360. doi: 10.3390/nu12113360.
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Systemic bee venom exerts anti-arthritic and anti-inflammatory properties in a rat model of arthritis.全身性蜂毒在大鼠关节炎模型中具有抗关节炎和抗炎特性。
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7
Effect of bee venom on reproductive performance and immune response of male rabbits.蜂毒对雄性兔子繁殖性能和免疫反应的影响。
Physiol Behav. 2020 Sep 1;223:112987. doi: 10.1016/j.physbeh.2020.112987. Epub 2020 May 31.
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Bee Updated: Current Knowledge on Bee Venom and Bee Envenoming Therapy.蜂更新：当前关于蜂毒液和蜂螫伤治疗的知识。
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Bee Venom: Overview of Main Compounds and Bioactivities for Therapeutic Interests.蜂毒：主要化合物概述及治疗相关的生物活性。
Molecules. 2019 Aug 19;24(16):2997. doi: 10.3390/molecules24162997.
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First Characterization of The Venom from , A Honeybee from The Middle East Region.首次对来自中东地区的一种蜜蜂毒液进行的描述。
Toxins (Basel). 2019 Mar 30;11(4):191. doi: 10.3390/toxins11040191.

蜂毒抗炎用途的自由基清除作用及热诱导蛋白质变性抑制作用的体外评估

In vitro Assessment of Free Radical Scavenging Effect and Thermal Protein Denaturation Inhibition of Bee Venom for an Anti-Inflammatory Use.

作者信息

Gîlcescu Florescu Camelia Alina, Stanciulescu Elena Camelia, Berbecaru-Iovan Anca, Balasoiu Roxana Maria, Pisoschi Catalina Gabriela

机构信息

Doctoral School, University of Medicine and Pharmacy of Craiova.

Department of Pharmaceutical Biochemistry, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova.

出版信息

Curr Health Sci J. 2024 Jan-Mar;50(1):81-86. doi: 10.12865/CHSJ.50.01.11. Epub 2024 Mar 31.

DOI:10.12865/CHSJ.50.01.11
PMID:38846469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11151940/
Abstract

Inflammation and the injuries produced by free radicals are interconnected and influence each other. The underlying mechanisms of inflammation are partially attributed to the release of free radicals by immune cells, prooxidants that can also cause protein alteration. This study was performed in order to assess the potential anti-inflammatory effect of two bee venom samples harvested from Apis mellifera. Free radical scavenging capacity was investigated using DPPH and ABTS.+ tests and protective effect on proteins through the inhibitory activity on thermal denaturation of albumin.

摘要

炎症与自由基产生的损伤相互关联且相互影响。炎症的潜在机制部分归因于免疫细胞释放自由基，这些促氧化剂也可导致蛋白质改变。本研究旨在评估从意大利蜜蜂采集的两种蜂毒样品的潜在抗炎作用。使用DPPH和ABTS +测试研究自由基清除能力，并通过对白蛋白热变性的抑制活性来研究其对蛋白质的保护作用。