Department of Chemistry, School of Physical and Chemical Sciences, Queen Mary University of London, Mile End Road, London, E1 4NS, UK.
Molecular Biosciences Division, School of Biosciences, Cardiff University, Cardiff, CF10 3AX, UK.
Chembiochem. 2022 Dec 5;23(23):e202200282. doi: 10.1002/cbic.202200282. Epub 2022 Nov 3.
Nanocarbon-based field-effect transistor (NC-FET) biosensors are at the forefront of future diagnostic technology. By integrating biological molecules with electrically conducting carbon-based platforms, high sensitivity real-time multiplexed sensing is possible. Combined with their small footprint, portability, ease of use, and label-free sensing mechanisms, NC-FETs are prime candidates for the rapidly expanding areas of point-of-care testing, environmental monitoring and biosensing as a whole. In this review we provide an overview of the basic operational mechanisms behind NC-FETs, synthesis and fabrication of FET devices, and developments in functionalisation strategies for biosensing applications.
基于纳米碳的场效应晶体管(NC-FET)生物传感器处于未来诊断技术的前沿。通过将生物分子与导电碳基平台集成,实现了高灵敏度的实时多重传感。结合其小尺寸、便携性、易用性和无标记传感机制,NC-FET 是即时检测、环境监测和生物传感等快速发展领域的首选。在这篇综述中,我们概述了 NC-FET 的基本工作机制、FET 器件的合成和制造,以及生物传感应用中的功能化策略的发展。