Roy Bapti, Iacopetta Bianca M, Peddle-McInytre Carolyn J, Donaghy Michaela, Ing Matthew, Tan Ai Ling, Lee Y C Gary
Pleural Medicine Unit Institute for Respiratory Health Perth Western Australia Australia.
Exercise Medicine Research Institute, School of Medical and Health Sciences Edith Cowan University Perth Western Australia Australia.
Respirol Case Rep. 2024 Jun 17;12(6):e01410. doi: 10.1002/rcr2.1410. eCollection 2024 Jun.
Pleural effusions often cause disabling breathlessness, however the mechanism is unknown. Patients with pleural effusions are subjected to pleural fluid drainage on a 'trial and error' basis, as symptom relief varies. This population commonly complain of bendopnoea (breathlessness on bending forward) which has not been investigated. Our pilot data found bendopnoea was significantly associated with presence of pleural effusion. The PLEASE-3 study will evaluate bendopnoea as a screening test for effusion-related breathlessness, its predictive value of symptomatic benefits from fluid drainage and explore its underlying physiological mechanism.
PLEASE-3 is a multi-centre prospective study. Eligible patients are assessed at baseline (pre-drainage) and for patients undergoing drainage, up to 72 h post-procedure. Outcome measures include the prevalence of bendopnoea, its correlation with size of effusion and its predictive value of breathlessness relief after drainage. The relationship of bendopnoea with breathlessness, physiological parameters, functional capacity and diaphragmatic characteristics will be assessed. The study will recruit 200 participants.
This is the first study to investigate bendopnoea in patients with pleural effusion. It has minimal exclusion criteria to ensure that the results are generalisable. The presence and clinical significance of bendopnoea in the context of pleural effusion requires thorough investigation. The post assessment of patients undergoing pleural fluid drainage will provide insight into whether the presence of bendopnoea is able to predict clinical outcomes.
Australia New Zealand Clinical Trial Registry ACTRN12622000465752. https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=383639&isReview=true Registered on 24 March 2022. This study has received funding from the Sir Charles Gairdner Research Advisory Council research project grant. The study is sponsored by the Institute for Respiratory Health, a not-for-profit organisation. Mr Bi Lam; Finance manager. Level 2, 6 Verdun Street, Nedlands WA 6009. t‖ + 61 8 6151 0877 e‖ bi.lam@resphealth.uwa.edu.au : The funder is not involved in the planning of the study, gathering, analysing, and interpreting the data, or in preparing the manuscript.
胸腔积液常导致使人丧失活动能力的呼吸困难，但其机制尚不清楚。胸腔积液患者通常在“反复试验”的基础上进行胸腔积液引流，因为症状缓解情况各不相同。这一人群普遍抱怨弯腰呼吸困难（向前弯腰时出现呼吸困难），但尚未对此进行研究。我们的初步数据发现，弯腰呼吸困难与胸腔积液的存在显著相关。PLEASE-3研究将评估弯腰呼吸困难作为与积液相关呼吸困难的筛查试验、其对胸腔积液引流后症状改善的预测价值，并探索其潜在的生理机制。
PLEASE-3是一项多中心前瞻性研究。符合条件的患者在基线（引流前）接受评估，对于接受引流的患者，在术后72小时内进行评估。观察指标包括弯腰呼吸困难的患病率、其与积液大小的相关性以及其对引流后呼吸困难缓解的预测价值。将评估弯腰呼吸困难与呼吸困难、生理参数、功能能力和膈肌特征之间的关系。该研究将招募200名参与者。
这是第一项研究胸腔积液患者弯腰呼吸困难的研究。它的排除标准极少，以确保结果具有普遍性。弯腰呼吸困难在胸腔积液背景下的存在及其临床意义需要深入研究。对接受胸腔积液引流患者的术后评估将有助于了解弯腰呼吸困难的存在是否能够预测临床结果。
澳大利亚新西兰临床试验注册中心ACTRN12622000465752。https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=383639&isReview=true 于2022年3月24日注册。本研究获得了查尔斯·盖尔德纳爵士研究咨询委员会研究项目资助。该研究由非营利组织呼吸健康研究所赞助。毕林先生；财务经理。西澳大利亚州内德兰兹韦尔登街6号2楼，邮编6009。电话：+61 8 6151 0877 邮箱：bi.lam@resphealth.uwa.edu.au ：资助者未参与研究的规划、数据的收集、分析和解释，也未参与稿件的撰写。
