Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, United States; UNC Microbiome Core, Center for Gastrointestinal Biology and Disease (CGIBD), School of Medicine, University of North Carolina, Chapel Hill, NC, United States.
UNC Microbiome Core, Center for Gastrointestinal Biology and Disease (CGIBD), School of Medicine, University of North Carolina, Chapel Hill, NC, United States; Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, United States; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh, Saudi Arabia.
Adv Nutr. 2024 Aug;15(8):100263. doi: 10.1016/j.advnut.2024.100263. Epub 2024 Jun 17.
The increasing prevalence of noncommunicable diseases in the aging population has been correlated with a decline in innate and adaptive immune responses; hence, it is imperative to identify approaches to improve immune function, prevent related disorders, and reduce or treat age-associated health complications. Prebiotic supplementation is a promising approach to modulate the gut microbiome and immune system, offering a potential strategy to maintain the integrity of immune function in older individuals. This review summarizes the current research on prebiotic galacto-oligosaccharide (GOS) immunomodulatory mechanisms mediated by bacterial-derived metabolites, including short-chain fatty acids and secondary bile acids, to maintain immune homeostasis. The potential applications of GOS as immunotherapy for age-related disease prevention in older individuals are also highlighted. This aligns with the global shift toward proactive healthcare and emphasizes the significance of early intervention in directing an individual's health trajectory.
随着老龄化人口中非传染性疾病的患病率不断上升，先天和适应性免疫反应呈下降趋势；因此，必须寻找改善免疫功能、预防相关疾病以及减少或治疗与年龄相关的健康并发症的方法。益生菌补充剂是一种很有前途的调节肠道微生物组和免疫系统的方法，为维持老年人免疫功能的完整性提供了一种潜在策略。本综述总结了目前关于益生菌半乳糖-低聚糖（GOS）通过细菌衍生代谢物（包括短链脂肪酸和次级胆汁酸）介导的免疫调节机制的研究，以维持免疫稳态。还强调了 GOS 作为免疫疗法在预防老年人与年龄相关疾病中的潜在应用。这与全球向主动保健的转变一致，并强调了早期干预在指导个人健康轨迹方面的重要性。
