Department of Virology, Faculty of Veterinary Medicine, Ondokuz Mayıs University, 55139 Samsun, Turkey.
Institute of Aquaculture, University of Stirling, Scotland FK9 4LA, UK.
Viruses. 2024 Jun 20;16(6):994. doi: 10.3390/v16060994.
Infectious pancreatic necrosis virus (IPNV) causes economic losses with a highly variable mortality rate worldwide, especially in rainbow trout. The virus has a double-stranded bi-partite RNA genome designated segment A and B. New complete genome sequences of nine rainbow trout isolates from Turkey were determined and subjected to phylogenetic analysis, identifying all as genotype 5 (serotype Sp). A time-dependent change in the extended pathogenicity motif of VP2 from P217T221A247 (PTA) to PTE P217T221E247 over a period of 10 years was identified. A wider analysis of 99 IPNV sequences from Turkey and Iran revealed the emergence of the motif PTE from 2007 to 2017, inducing significant morbidity in fry by 2013. In fact, displacement of the PTA motif, by the PTE motif in IPNV isolates appeared to be connected to a production peak of rainbow trout in 2013. An additional CAI analysis provided more evidence, indicating that rainbow trout culture in Turkey has an influence on the evolution of IPNV.
传染性胰脏坏死病毒 (IPNV) 在全球范围内造成了严重的经济损失，死亡率变化很大，尤其是在虹鳟鱼中。该病毒具有双链二分体 RNA 基因组，分别命名为 A 节和 B 节。从土耳其确定了 9 个虹鳟鱼分离株的完整新基因组序列，并进行了系统发育分析，结果均鉴定为 5 型（血清型 Sp）。经过 10 年的时间，VP2 的扩展致病性基序从 P217T221A247 (PTA) 逐渐变为 PTE P217T221E247。对来自土耳其和伊朗的 99 个 IPNV 序列进行更广泛的分析表明，2007 年至 2017 年间出现了 PTE 基序，到 2013 年，该基序引起了鱼苗的高发病率。事实上，IPNV 分离株中 PTA 基序被 PTE 基序取代似乎与 2013 年虹鳟鱼产量达到峰值有关。额外的 CAI 分析提供了更多证据，表明土耳其的虹鳟鱼养殖对 IPNV 的进化有影响。
