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1
Studies on the control of antibody synthesis. XIII. Preferential depeletion of precursors of high affinity antibody-secreting cells by specific immunoadsorbents.抗体合成控制的研究。十三。特异性免疫吸附剂对高亲和力抗体分泌细胞前体的优先耗竭。
Immunology. 1979 Sep;38(1):145-56.
2
Ontogeny of B-lymphocyte function. IX. Difference in the time of maturation of the capacity of B lymphocytes from foetal and neonatal mice to produce a heterogeneous antibody response to thymic-dependent and thymic-independent antigens.B淋巴细胞功能的个体发生。IX. 胎鼠和新生鼠B淋巴细胞对胸腺依赖性和胸腺非依赖性抗原产生异质性抗体反应能力的成熟时间差异。
Immunology. 1979 Apr;36(4):891-907.
3
DNP-Lys-ficoll: a T-independent antigen which elicits both IgM and IgG anti-DNP antibody-secreting cells.二硝基苯赖氨酸-聚蔗糖：一种非T细胞依赖性抗原，可引发分泌IgM和IgG抗二硝基苯抗体的细胞。
J Immunol. 1975 May;114(5):1585-9.
4
Studies on the control of antibody synthesis. VII. Change in affinity of direct and indirect plaque-forming cells with time after immunization in the mouse: loss of high affinity plaques late after immunization.抗体合成控制的研究。VII. 小鼠免疫后直接和间接噬斑形成细胞亲和力随时间的变化：免疫后期高亲和力噬斑的丧失
Immunology. 1975 Oct;29(4):629-41.
5
The generation of memory cells. IV. Immunization with antigen-antibody complexes accelerates the development of B-memory cells, the formation of germinal centres and the maturation of antibody affinity in the secondary response.记忆细胞的产生。IV. 用抗原-抗体复合物进行免疫可加速二次免疫应答中B记忆细胞的发育、生发中心的形成以及抗体亲和力的成熟。
Immunology. 1981 Jun;43(2):371-8.
6
Ontogeny of T cell function. I. Acquisition of helper cell activity by the thymus.T细胞功能的个体发生。I. 胸腺辅助细胞活性的获得。
J Immunol. 1980 Apr;124(4):1878-82.
7
The mechanism of thymus-dependent antibody formation in bone marrow.骨髓中胸腺依赖抗体形成的机制。
J Immunol. 1981 Apr;126(4):1447-51.
8
The generation of memory cells. V. Preferential priming of IgG1 B memory cells by immunization with antigen IgG2 antibody complexes.记忆细胞的产生。V. 用抗原IgG2抗体复合物免疫对IgG1 B记忆细胞的优先启动。
Immunology. 1981 Sep;44(1):163-8.
9
Studies on the control of antibody synthesis. XVII. Effect of specific suppressor cells on the affinity of the antibody response by naive or primed lymphocytes.抗体合成控制的研究。十七。特异性抑制细胞对未致敏或已致敏淋巴细胞抗体应答亲和力的影响。
Immunology. 1980 Jun;40(2):255-64.
10
Antigen specific receptors on murine B cell lineage. 1. On antibody forming cells in various stages of immune response.小鼠B细胞系上的抗原特异性受体。1. 关于免疫应答不同阶段的抗体形成细胞。
Jpn J Exp Med. 1980 Aug;50(4):237-43.

本文引用的文献

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The use of antigen-coated glass as a specific adsorbent for antibody.使用抗原包被玻璃作为抗体的特异性吸附剂。
J Immunol. 1958 Apr;80(4):294-8.
2
Specific inactivation of antigen-reactive cells with 125I-labelled antigen.用125I标记的抗原特异性灭活抗原反应性细胞。
Nature. 1969 Jun 28;222(5200):1291-2. doi: 10.1038/2221291a0.
3
Cell separation on antigen-coated columns. Elimination of high rate antibody-forming cells and immunological memory cells.抗原包被柱上的细胞分离。去除高速率抗体形成细胞和免疫记忆细胞。
J Exp Med. 1969 Jan 1;129(1):23-36. doi: 10.1084/jem.129.1.23.
4
Antitrinitrophenyl (TNP) plaque assay. Primary response of Balb/c mice to soluble and particulate immunogen.抗三硝基苯基（TNP）空斑试验。Balb/c小鼠对可溶性和颗粒性免疫原的初次反应。
Proc Soc Exp Biol Med. 1969 Nov;132(2):575-81. doi: 10.3181/00379727-132-34264.
5
Studies on antibody affinity at the cellular level. Correlation between binding properties of secreted antibody and cellular receptor for antigen on immunological memory cells.细胞水平上抗体亲和力的研究。分泌抗体的结合特性与免疫记忆细胞上抗原细胞受体之间的相关性。
J Exp Med. 1972 Feb 1;135(2):312-22. doi: 10.1084/jem.135.2.312.
6
Studies on the regulation of avidity at the level of the single antibody-forming cell. The effect of antigen dose and time after immunization.关于单个抗体形成细胞水平亲和力调节的研究。抗原剂量和免疫后时间的影响。
J Exp Med. 1970 Jul 1;132(1):77-88. doi: 10.1084/jem.132.1.77.
7
Specific separation of cells on affinity columns.亲和柱上细胞的特异性分离。
Proc Natl Acad Sci U S A. 1970 Jul;66(3):685-92. doi: 10.1073/pnas.66.3.685.
8
Cell selection by antigen in the immune response.免疫应答中抗原介导的细胞选择。
Adv Immunol. 1969;10:1-50. doi: 10.1016/s0065-2776(08)60414-9.
9
Plaque forming cells: methodology and theory.噬斑形成细胞：方法与理论
Transplant Rev. 1974;18:130-91. doi: 10.1111/j.1600-065x.1974.tb01588.x.
10
Studies on the control of antibody synthesis. 3. Changes in heterogeneity of antibody affinity during the course of the immune response.抗体合成控制的研究。3. 免疫反应过程中抗体亲和力异质性的变化。
Immunology. 1973 Mar;24(3):477-92.

抗体合成控制的研究。十三。特异性免疫吸附剂对高亲和力抗体分泌细胞前体的优先耗竭。

Studies on the control of antibody synthesis. XIII. Preferential depeletion of precursors of high affinity antibody-secreting cells by specific immunoadsorbents.

作者信息

Slankard-Chahinian M, Siskind G W

出版信息

Immunology. 1979 Sep;38(1):145-56.

PMID:389778
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457890/
Abstract

Passage of spleen or bone marrow cells from non-immunized donors through a DNP-Ova coated Degalan bead immunoadsorbent column resulted in a specific depletion of the ability of the cell population to restore the anti-DNP antibody response to DNP-BGG by lethally irradiated mice. There was a preferential depletion of precursors of high affinity antibody-secreting cells which is consistent with the view that these cells bear high affinity antigen receptors. The cell population passed through the immunoadsorbent column was also preferentially depleted of the capacity to produce high affinity direct anti-DNP PFC in comparison with thigh affinity indirect anti-DNP PFC. These findings suggest, but do not prove, that different subpopulations of antigen-binding cells are precursors for direct and indirect PFC.

摘要

将来自未免疫供体的脾细胞或骨髓细胞通过包被有二硝基苯-卵清蛋白（DNP-Ova）的德格朗珠免疫吸附柱，导致该细胞群体恢复经致死剂量照射的小鼠对二硝基苯-马血清白蛋白（DNP-BGG）的抗二硝基苯抗体反应的能力出现特异性耗竭。高亲和力抗体分泌细胞的前体出现优先耗竭，这与这些细胞带有高亲和力抗原受体的观点一致。与低亲和力间接抗二硝基苯空斑形成细胞（PFC）相比，通过免疫吸附柱的细胞群体产生高亲和力直接抗二硝基苯PFC的能力也出现优先耗竭。这些发现提示（但未证实），抗原结合细胞的不同亚群是直接和间接PFC的前体。