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从一源多成分角度分析中药生姜的药理活性及临床应用

Pharmacological activity and clinical application analysis of traditional Chinese medicine ginger from the perspective of one source and multiple substances.

作者信息

Zhang Cheng, Rao Anyang, Chen Cui, Li Yuqing, Tan Xiuchi, Long Jiaxin, Wang Xinyue, Cai Junjie, Huang Jiquan, Luo Hua, Li Chuwen, Dang Yuanye

机构信息

Department of Pharmacy, Chengdu University of Traditional Chinese, Medicine, Chengdu, 611137, China.

Hongxing Town Government of Ruoergai County, Aba Tibetan and Qiang Autonomous Prefecture, Sichuan, 624504, China.

出版信息

Chin Med. 2024 Jul 12;19(1):97. doi: 10.1186/s13020-024-00969-z.

Abstract

All types of ginger have common fundamental components, although they possess distinct strengths and inclinations when it comes to effectiveness and medicinal applications. Fresh ginger possesses the ability to effectively stimulate movement within the body, alleviate the act of vomiting, induce sweating, and provide relief for external syndromes. Dried ginger possesses both defensive and stimulant characteristics, which effectively raise the internal temperature and enhance the Yang energy. Fresh ginger is more hydrating than dried ginger, highly skilled at heating the Middle-jiao, alleviating pain, halting bleeding, and managing diarrhea. Dried ginger possesses the ability to alleviate coldness when consumed in a heated form, as well as to alleviate diarrhea when consumed in a heated form. It thrives in warm conditions and has a tendency to revert back to its warm nature. The moisture content of baked ginger is inferior to that of dried ginger, but it is highly effective in alleviating pain, bleeding, and diarrhea by warming the Middle-jiao. Ginger charcoal and stir-fried charcoal, produced through carbonization, have excellent heat retention properties and are effective in warming meridians and stopping bleeding. The potency and ability to spread of roasted ginger is less intense compared to fresh ginger, and its moisture content is not as low as that of dried ginger. The medicinal characteristics of this substance are gentle, making it beneficial for alleviating vomiting in patients who are physically frail. Its primary mode of action is on the Middle-jiao. Nevertheless, the main chemical compositions of various traditional Chinese medicines are nearly identical due to their shared base element. Ginger, in particular, possesses a range of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-bacterial, and anticoagulant properties. However, modern pharmacological research has not fully acknowledged the clinical medicinal value of ginger and consequently, fails to provide accurate guidance for clinical medication. This situation has a negative impact on the contemporary advancement of traditional Chinese medicine (TCM). The research on modernizing ginger is conducted by analyzing and considering the prospects. It is based on Traditional Chinese Medicine (TCM) theory and incorporates the comprehensive perspective of TCM philosophy. In order to modernize ginger, it is essential to have a proper knowledge of the concepts of "recognizing nature by efficacy, homology, and mutual expression of nature and efficacy" and "rationally utilizing modern drug research technology". By applying these principles, we can construct a bridge towards the advancement of ginger.

摘要

所有类型的姜都有共同的基本成分,尽管它们在功效和药用应用方面具有不同的优势和倾向。鲜姜能够有效地促进体内的气血运行,缓解呕吐,发汗,并缓解表证。干姜具有防御和刺激的特性,能有效地提高体内温度,增强阳气。鲜姜比干姜更具滋润性,擅长温煦中焦、止痛、止血和止泻。干姜加热服用时能够散寒,加热服用时也能止泻。它在温暖的环境中生长良好,并且有恢复其温热性质的倾向。炮姜的含水量低于干姜,但通过温煦中焦,在止痛、止血和止泻方面非常有效。通过碳化制成的姜炭和炒炭具有优异的保温性能,能有效地温经止血。炮姜的药力和发散能力比鲜姜弱,其含水量也不像干姜那么低。这种物质的药用特性较为温和,有利于缓解身体虚弱患者的呕吐。其主要作用部位在中焦。然而,由于各种中药的共同基础元素,它们的主要化学成分几乎相同。特别是姜,具有一系列药理活性,包括抗氧化、抗炎、抗肿瘤、抗菌和抗凝特性。然而,现代药理学研究尚未充分认识到姜的临床药用价值,因此未能为临床用药提供准确指导。这种情况对中医的当代发展产生了负面影响。对姜进行现代化研究是通过分析和考虑前景来进行的。它基于中医理论,并纳入了中医哲学的综合视角。为了使姜现代化,必须正确理解“以功效、同源性和性味与功效的相互表达来认识药性”以及“合理利用现代药物研究技术”的概念。通过应用这些原则,我们可以搭建一座推动姜发展的桥梁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ef4e/11241951/d7b5899c5029/13020_2024_969_Fig1_HTML.jpg

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