Akar Kadir, Holzer Katharina, Hoelzle Ludwig E, Yıldız Öz Gülseren, Abdelmegid Shaimaa, Baklan Emin Ayhan, Eroğlu Buket, Atıl Eray, Moustafa Shawky A, Wareth Gamal, Elkhayat Manar
Faculty of Veterinary Medicine, Van Yuzuncu Yıl University, 65090 Van, Turkey.
Department of Livestock Infectiology and Environmental Hygiene, Institute of Animal Science, University of Hohenheim, 70599 Stuttgart, Germany.
Vet Sci. 2024 Jul 14;11(7):316. doi: 10.3390/vetsci11070316.
Brucellosis is a disease caused by the () species. It is a zoonotic disease that affects farm animals and causes economic losses in many countries worldwide. has the ability to persist in the environment and infect the host at low doses. Thus, it is more important to trace brucellosis outbreaks, identify their sources of infection, and interrupt their transmission. Some countries already have initial data, but most of these data are based on a Multiple-Locus Variable-Number Tandem-Repeat Analysis (MLVA), which is completely unsuitable for studying the genome. Since brucellosis is an endemic disease in Turkey, this study aimed to examine the genome of Turkish isolates collected between 2018 and 2020, except for one isolate, which was from 2012. A total of 28 strains of ( = 15) and ( = 13) were analyzed using a core-genome single-nucleotide polymorphism (cgSNP) analysis. A potential connection between the Turkish isolates and entries from Sweden, Israel, Syria, Austria, and India for was detected. For , there may be potential associations with entries from China. This explains the tight ties found between strains from neighboring countries and isolates from Turkey. Therefore, it is recommended that strict measures be taken and the possible effects of uncontrolled animal introduction are emphasized.
布鲁氏菌病是由（）物种引起的一种疾病。它是一种人畜共患病，会影响农场动物，并在全球许多国家造成经济损失。（病原体）有能力在环境中持续存在，并以低剂量感染宿主。因此，追踪布鲁氏菌病疫情、确定其感染源并阻断其传播更为重要。一些国家已经有了初步数据，但其中大部分数据基于多位点可变数目串联重复序列分析（MLVA），这完全不适用于研究（病原体）基因组。由于布鲁氏菌病在土耳其是一种地方病，本研究旨在检测2018年至2020年间收集的土耳其（病原体）分离株的基因组，但有一个分离株来自2012年。使用核心基因组单核苷酸多态性（cgSNP）分析对总共28株（=15）（一种病原体）和（=13）（另一种病原体）进行了分析。检测到土耳其分离株与来自瑞典、以色列、叙利亚、奥地利和印度的（一种病原体）条目之间存在潜在联系。对于（另一种病原体），可能与来自中国的条目存在潜在关联。这解释了在邻国的（病原体）菌株与土耳其分离株之间发现的紧密联系。因此，建议采取严格措施，并强调不受控制地引入动物可能产生的影响。
