新生儿单纯疱疹病毒黏膜部位检测。

Mucosal Site Detection of Herpes Simplex Virus in Neonates.

机构信息

The Ohio State University College of Medicine, Columbus, OH; Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH.

Division of Neonatology, Department of Pediatrics, Nationwide Children's Hospital, Abigail Wexner Research Institute at Nationwide Children's Hospital, Center for Perinatal Research, Ohio Perinatal Research Network, Columbus, OH; Department of Pediatrics, Hospital Universitario del Valle, Universidad del Valle, Cali, Colombia.

出版信息

J Pediatr. 2024 Dec;275:114212. doi: 10.1016/j.jpeds.2024.114212. Epub 2024 Jul 24.

DOI:10.1016/j.jpeds.2024.114212

PMID:39059717

Abstract

From 2001 to 2023, 17 (14%) of 120 neonates with confirmed herpes simplex virus infection tested positive for herpes simplex virus by polymerase chain reaction (PCR) from only mucosal sites without a clinical mucosal lesion. Whether mucosal PCR positivity reflects early infection that may lead to recognizable disease, transient colonization, or a false-positive PCR result remains a clinical conundrum and warrants further study.

摘要

从 2001 年到 2023 年，在 120 例确诊单纯疱疹病毒感染的新生儿中，有 17 例（14%）仅从黏膜部位通过聚合酶链反应（PCR）检测到单纯疱疹病毒阳性，而这些新生儿没有临床黏膜病变。黏膜 PCR 阳性是否反映了可能导致可识别疾病、短暂定植或假阳性 PCR 结果的早期感染，这仍然是一个临床难题，需要进一步研究。