Pham Emily, Reynolds-Reber Landrye, Navarro Stephany, Hamood Abdul, Jones-Donaldson Laura M, Smith Allie Clinton
Department of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Department of Honors Studies, Texas Tech University, Lubbpock, TX 79409, USA.
Diagnostics (Basel). 2024 Jul 10;14(14):1474. doi: 10.3390/diagnostics14141474.
Chronic wound infections are of clinical concern as they often lead to high rates of mortality and morbidity. A point-of-care handheld bacterial fluorescence imaging has been designed to detect the auto-fluorescent characteristics of most clinically relevant species of bacteria. This device causes most species of bacteria to exhibit red fluorescence due to the production of exoproduct porphyrins. One of the most significant contributors to the pathogenicity of chronic wounds is the pathogen , and interestingly, this organism exhibits an additional unique cyan fluorescence signature. There is an over 90% positive predictive value that, when a chronic wound exhibits cyan fluorescence with the bacterial fluorescence imaging device, the wound will harbor . This project seeks to understand what genetic factor(s) contribute to the cyan phenotype observed.
慢性伤口感染是临床上关注的问题，因为它们常常导致高死亡率和高发病率。一种即时检测手持式细菌荧光成像设备已被设计用于检测大多数临床相关细菌物种的自发荧光特性。该设备会使大多数细菌物种由于外产物卟啉的产生而呈现红色荧光。慢性伤口致病性的最重要因素之一是病原体，有趣的是，这种微生物呈现出一种额外独特的青色荧光特征。当慢性伤口在细菌荧光成像设备下呈现青色荧光时，该伤口含有该病原体的阳性预测值超过90%。本项目旨在了解导致观察到的青色表型的遗传因素。
