Xu Jiamin, Mu Shukun, Wang Yun, Yu Suchun, Wang Zhongming
School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China.
Department of Radiation Oncology, Shidong Hospital, Yangpu District, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai, China.
Front Oncol. 2024 Jul 16;14:1400193. doi: 10.3389/fonc.2024.1400193. eCollection 2024.
The incidence of melanoma is increasing year by year and is highly malignant, with a poor prognosis. Its treatment has always attracted much attention. Among the more clinically applied immunotherapies are immune checkpoint inhibitors, bispecific antibodies, cancer vaccines, adoptive cell transfer therapy, and oncolytic virotherapy. With the continuous development of technology and trials, in addition to immune monotherapy, combinations of immunotherapy and radiotherapy have shown surprising efficacy. In this article, we review the research progress of immune monotherapy and combination therapy for advanced melanoma, with the aim of providing new ideas for the treatment strategy for advanced melanoma.
黑色素瘤的发病率逐年上升，且恶性程度高，预后较差。其治疗一直备受关注。在临床上应用较多的免疫疗法包括免疫检查点抑制剂、双特异性抗体、癌症疫苗、过继性细胞转移疗法和溶瘤病毒疗法。随着技术的不断发展和试验的进行，除了免疫单药治疗外，免疫疗法与放射疗法的联合已显示出惊人的疗效。在本文中，我们综述了晚期黑色素瘤免疫单药治疗和联合治疗的研究进展，旨在为晚期黑色素瘤的治疗策略提供新思路。
