中国人体和动物宿主中卫氏并殖吸虫和斯氏狸殖吸虫的感染和生物地理学特征：系统评价和荟萃分析。
Infection and biogeographical characteristics of Paragonimus westermani and P. skrjabini in humans and animal hosts in China: A systematic review and meta-analysis.
机构信息
School of Public Health, Shandong Second Medical University, Weifang, Shandong, P.R. China.
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention; Chinese Center for Tropical Diseases Research; National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases; Key Laboratory on Parasite and Vector Biology, Ministry of Health; WHO Collaborating Centre for Tropical Diseases; National Center for International Research on Tropical Diseases, Ministry of Science and Technology, Shanghai, P.R. China.
出版信息
PLoS Negl Trop Dis. 2024 Aug 5;18(8):e0012366. doi: 10.1371/journal.pntd.0012366. eCollection 2024 Aug.
BACKGROUND
Paragonimiasis, primarily caused by Paragonimus westermani and P. skrjabini in China, is a common food-borne parasitic zoonosis. However, the national distribution of Paragonimus spp. infection and its associated environmental determinants remain poorly understood. In this paper, we summarize the infection of P. westermani and P. skrjabini and describe key biogeographical characteristics of the endemic areas in China.
METHODS
Data on Paragonimus infection in humans and animal hosts were extracted from eight electronic databases, including CNKI, CWFD, Chongqing VIP, SinoMed, Medline, Embase, PubMed, and Web of Science. A random-effects meta-analysis model was used to estimate the pooled prevalence. All survey locations were georeferenced and plotted on China map, and scatter plots were used to illustrate the biogeographical characteristics of regions reporting Paragonimus infection.
RESULTS
A total of 28,948 cases of human paragonimiasis have been documented, with 2,401 cases reported after 2010. Among the 11,443 cases with reported ages, 88.05% were children or adolescents. The pooled prevalence of P. skrjabini is 0.45% (95% CI: 0.27-0.66%) in snails, 31.10% (95% CI: 24.77-37.80%) in the second intermediate host, and 20.31% (95% CI: 9.69-33.38%) in animal reservoirs. For P. westermani, the pooled prevalence is 0.06% (95% CI: 0.01-0.13%) in snails, 52.07% (95% CI: 43.56-60.52%) in the second intermediate host, and 21.40% (95% CI: 7.82-38.99%) in animal reservoirs. Paragonimus are primarily distributed in regions with low altitude, high temperature, and high precipitation. In northeastern China, only P. westermani infections have been documented, while in more southern areas, infections of both P. westermani and P. skrjabini have been reported.
CONCLUSIONS
Paragonimiasis remains prevalent in China, particularly among children and adolescents. Variations exist in the intermediate hosts and geographical distribution of P. westermani and P. skrjabini. Additionally, altitude, temperature, and precipitation may influence the distribution of Paragonimus.
背景
在中国，卫氏并殖吸虫和斯氏狸殖吸虫是主要的致病寄生虫，可引起并殖吸虫病，这是一种常见的食源性寄生虫病。然而，目前对并殖吸虫病的全国分布及其相关环境决定因素仍了解甚少。本文总结了卫氏并殖吸虫和斯氏狸殖吸虫的感染情况，并描述了中国流行地区的关键生物地理特征。
方法
从中国知网、维普网、重庆维普、中国生物医学文献数据库、中国生物医学引文数据库、PubMed、Medline、Embase 和 Web of Science 等 8 个电子数据库中提取有关人类和动物宿主感染并殖吸虫的数据。采用随机效应荟萃分析模型估计汇总患病率。所有调查地点均进行地理定位，并绘制在中国地图上，散点图用于说明报告有并殖吸虫感染的地区的生物地理特征。
结果
共记录了 28948 例人类并殖吸虫病，其中 2010 年后报告了 2401 例。在有报告年龄的 11443 例病例中，88.05%为儿童或青少年。在蜗牛中，斯氏狸殖吸虫的总流行率为 0.45%（95%CI：0.27-0.66%），第二中间宿主为 31.10%（95%CI：24.77-37.80%），动物宿主为 20.31%（95%CI：9.69-33.38%）。对于卫氏并殖吸虫，在蜗牛中流行率为 0.06%（95%CI：0.01-0.13%），第二中间宿主为 52.07%（95%CI：43.56-60.52%），动物宿主为 21.40%（95%CI：7.82-38.99%）。并殖吸虫主要分布在海拔较低、温度较高和降水较多的地区。在中国东北地区，仅记录了卫氏并殖吸虫感染，而在更南部地区，同时报告了卫氏并殖吸虫和斯氏狸殖吸虫感染。
结论
并殖吸虫病在中国仍然流行，特别是在儿童和青少年中。卫氏并殖吸虫和斯氏狸殖吸虫的中间宿主和地理分布存在差异。此外，海拔、温度和降水可能会影响并殖吸虫的分布。
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