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人工智能辅助三阴性乳腺癌亚分型、诊断和治疗的进展:重点综述。

Advancements in triple-negative breast cancer sub-typing, diagnosis and treatment with assistance of artificial intelligence : a focused review.

机构信息

Center for High Altitude Medicine, West China Hospital, Sichuan University, Chengdu, 610041, China.

West China Tianfu Hospital, Sichuan University, Chengdu, Sichuan, 610218, China.

出版信息

J Cancer Res Clin Oncol. 2024 Aug 6;150(8):383. doi: 10.1007/s00432-024-05903-2.


DOI:10.1007/s00432-024-05903-2
PMID:39103624
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11300496/
Abstract

Triple negative breast cancer (TNBC) is most aggressive type of breast cancer with multiple invasive sub-types and leading cause of women's death worldwide. Lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER-2) causes it to spread rapidly making its treatment challenging due to unresponsiveness towards anti-HER and endocrine therapy. Hence, needing advanced therapeutic treatments and strategies in order to get better recovery from TNBC. Artificial intelligence (AI) has been emerged by giving its high inputs in the automated diagnosis as well as treatment of several diseases, particularly TNBC. AI based TNBC molecular sub-typing, diagnosis as well as therapeutic treatment has become successful now days. Therefore, present review has reviewed recent advancements in the role and assistance of AI particularly focusing on molecular sub-typing, diagnosis as well as treatment of TNBC. Meanwhile, advantages, certain limitations and future implications of AI assistance in the TNBC diagnosis and treatment are also discussed in order to fully understand readers regarding this issue.

摘要

三阴性乳腺癌(TNBC)是最具侵袭性的乳腺癌类型,具有多种侵袭性亚型,是全球女性死亡的主要原因。由于缺乏雌激素受体(ER)、孕激素受体(PR)和人表皮生长因子受体 2(HER-2),它会迅速扩散,导致对 HER-2 靶向治疗和内分泌治疗的反应不佳。因此,需要先进的治疗方法和策略,以从 TNBC 中获得更好的康复。人工智能(AI)通过在多种疾病的自动诊断和治疗中提供大量投入而出现,特别是 TNBC。基于 AI 的 TNBC 分子亚型、诊断和治疗现在已经取得了成功。因此,本综述回顾了 AI 在 TNBC 中的作用和辅助作用的最新进展,特别是侧重于 TNBC 的分子亚型、诊断和治疗。同时,还讨论了 AI 在 TNBC 诊断和治疗中的优势、某些局限性和未来影响,以便读者充分了解这一问题。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/22a2679d6b2b/432_2024_5903_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/dc557f0ce74e/432_2024_5903_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/7228751416a8/432_2024_5903_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/22a2679d6b2b/432_2024_5903_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/dc557f0ce74e/432_2024_5903_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/7228751416a8/432_2024_5903_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b2ea/11300496/22a2679d6b2b/432_2024_5903_Fig3_HTML.jpg

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[1]
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引用本文的文献

[1]
Development and validation of a predictive model for disease-free progression in triple-negative breast cancer: A retrospective study using color Doppler ultrasound and magnetic resonance imaging.

Breast. 2025-8-22

[2]
Advances in nanoparticle-based doxorubicin delivery: precision strategies for targeted treatment of triple-negative breast cancer.

Discov Nano. 2025-7-14

[3]
Exploring graph-based models for predicting active compounds against triple-negative breast cancer.

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[4]
Extracellular vesicles in triple-negative breast cancer: current updates, challenges and future prospects.

Front Mol Biosci. 2025-4-14

[5]
Radiologic imaging biomarkers in triple-negative breast cancer: a literature review about the role of artificial intelligence and the way forward.

BJR Artif Intell. 2024-11-13

[6]
Potential Therapeutic Targets in Triple-Negative Breast Cancer Based on Gene Regulatory Network Analysis: A Comprehensive Systems Biology Approach.

Int J Breast Cancer. 2024-10-22

本文引用的文献

[1]
New Frontiers in Breast Cancer Imaging: The Rise of AI.

Bioengineering (Basel). 2024-5-2

[2]
A guide to artificial intelligence for cancer researchers.

Nat Rev Cancer. 2024-6

[3]
Subtyping of triple-negative breast cancers: its prognostication and implications in diagnosis of breast origin.

ESMO Open. 2024-4

[4]
Triple-negative breast cancer survival prediction using artificial intelligence through integrated analysis of tertiary lymphoid structures and tumor budding.

Cancer. 2024-4-15

[5]
A Prognostic Model of Genetic Markers for Triple-Negative Breast Cancer Based on Machine Learning and Bioinformatics Analysis.

Stud Health Technol Inform. 2023-11-23

[6]
Applications of discriminative and deep learning feature extraction methods for whole slide image analysis: A survey.

J Pathol Inform. 2023-9-14

[7]
Artificial intelligence in breast cancer: application and future perspectives.

J Cancer Res Clin Oncol. 2023-11

[8]
Artificial intelligence reveals features associated with breast cancer neoadjuvant chemotherapy responses from multi-stain histopathologic images.

NPJ Precis Oncol. 2023-1-27

[9]
Artificial intelligence-based digital scores of stromal tumour-infiltrating lymphocytes and tumour-associated stroma predict disease-specific survival in triple-negative breast cancer.

J Pathol. 2023-5

[10]
Prediction of pathologic complete response to neoadjuvant systemic therapy in triple negative breast cancer using deep learning on multiparametric MRI.

Sci Rep. 2023-1-20

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