• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

jmBIG:通过对大规收集数据中的纵向和生存数据进行联合建模,增强动态风险预测和个性化医学。

jmBIG: enhancing dynamic risk prediction and personalized medicine through joint modeling of longitudinal and survival data in big routinely collected data.

机构信息

Population Health and Genomics, University of Dundee, Dundee, UK.

Department of Mathematics and Computing, Indian Institute of Technology-Dhanbad, Dhanbad, India.

出版信息

BMC Med Res Methodol. 2024 Aug 6;24(1):172. doi: 10.1186/s12874-024-02289-0.

DOI:10.1186/s12874-024-02289-0
PMID:39107693
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11301890/
Abstract

We have introduced the R package jmBIG to facilitate the analysis of large healthcare datasets and the development of predictive models. This package provides a comprehensive set of tools and functions specifically designed for the joint modelling of longitudinal and survival data in the context of big data analytics. The jmBIG package offers efficient and scalable implementations of joint modelling algorithms, allowing for integrating large-scale healthcare datasets.By utilizing the capabilities of jmBIG, researchers and analysts can effectively handle the challenges associated with big healthcare data, such as high dimensionality and complex relationships between multiple outcomes.With the support of jmBIG, analysts can seamlessly fit Bayesian joint models, generate predictions, and evaluate the performance of the models. The package incorporates cutting-edge methodologies and harnesses the computational capabilities of parallel computing to accelerate the analysis of large-scale healthcare datasets significantly. In summary, jmBIG empowers researchers to gain deeper insights into disease progression and treatment response, fostering evidence-based decision-making and paving the way for personalized healthcare interventions that can positively impact patient outcomes on a larger scale.

摘要

我们引入了 R 包 jmBIG,以方便对大型医疗保健数据集进行分析并开发预测模型。这个包提供了一整套工具和功能,专门针对大数据分析环境中的纵向和生存数据的联合建模而设计。jmBIG 包提供了高效和可扩展的联合建模算法实现,允许集成大规模的医疗保健数据集。通过利用 jmBIG 的功能,研究人员和分析师可以有效地处理与大型医疗保健数据相关的挑战,如高维性和多个结果之间的复杂关系。有了 jmBIG 的支持,分析师可以无缝地拟合贝叶斯联合模型、生成预测,并评估模型的性能。该包采用了最先进的方法,并利用并行计算的计算能力,大大加速了大规模医疗保健数据集的分析。总之,jmBIG 使研究人员能够更深入地了解疾病进展和治疗反应,促进基于证据的决策,并为个性化医疗干预铺平道路,从而在更大范围内对患者结果产生积极影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/0ea93867ea6f/12874_2024_2289_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/60419166ec9d/12874_2024_2289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/7d8bca56ba35/12874_2024_2289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/862a3ae62607/12874_2024_2289_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/38e04b60c847/12874_2024_2289_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/fbfe7ca75a13/12874_2024_2289_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/0ea93867ea6f/12874_2024_2289_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/60419166ec9d/12874_2024_2289_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/7d8bca56ba35/12874_2024_2289_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/862a3ae62607/12874_2024_2289_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/38e04b60c847/12874_2024_2289_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/fbfe7ca75a13/12874_2024_2289_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3058/11301890/0ea93867ea6f/12874_2024_2289_Fig6_HTML.jpg

相似文献

1
jmBIG: enhancing dynamic risk prediction and personalized medicine through joint modeling of longitudinal and survival data in big routinely collected data.jmBIG:通过对大规收集数据中的纵向和生存数据进行联合建模,增强动态风险预测和个性化医学。
BMC Med Res Methodol. 2024 Aug 6;24(1):172. doi: 10.1186/s12874-024-02289-0.
2
Framework for personalized prediction of treatment response in relapsing remitting multiple sclerosis.复发缓解型多发性硬化症个体化治疗反应预测的框架。
BMC Med Res Methodol. 2020 Feb 7;20(1):24. doi: 10.1186/s12874-020-0906-6.
3
Detecting disease-associated genomic outcomes using constrained mixture of Bayesian hierarchical models for paired data.使用贝叶斯分层模型的约束混合方法对配对数据检测疾病相关基因组结果。
PLoS One. 2017 Mar 30;12(3):e0174602. doi: 10.1371/journal.pone.0174602. eCollection 2017.
4
Joint modelling of time-to-event and multivariate longitudinal outcomes: recent developments and issues.事件发生时间与多变量纵向结果的联合建模:最新进展与问题
BMC Med Res Methodol. 2016 Sep 7;16(1):117. doi: 10.1186/s12874-016-0212-5.
5
An R Package for Bayesian Analysis of Multi-environment and Multi-trait Multi-environment Data for Genome-Based Prediction.用于基于基因组预测的多环境和多性状多环境数据的贝叶斯分析的 R 包。
G3 (Bethesda). 2019 May 7;9(5):1355-1369. doi: 10.1534/g3.119.400126.
6
Compressive Big Data Analytics: An ensemble meta-algorithm for high-dimensional multisource datasets.压缩大数据分析:一种用于高维多源数据集的集成元算法。
PLoS One. 2020 Aug 28;15(8):e0228520. doi: 10.1371/journal.pone.0228520. eCollection 2020.
7
Innovations in Genomics and Big Data Analytics for Personalized Medicine and Health Care: A Review.基因组学和大数据分析在个性化医疗和医疗保健中的创新:综述。
Int J Mol Sci. 2022 Apr 22;23(9):4645. doi: 10.3390/ijms23094645.
8
Transforming Healthcare Delivery: Integrating Dynamic Simulation Modelling and Big Data in Health Economics and Outcomes Research.变革医疗服务提供:将动态模拟建模与大数据整合于卫生经济学和结果研究中。
Pharmacoeconomics. 2016 Feb;34(2):115-26. doi: 10.1007/s40273-015-0330-7.
9
Bayesian Networks for Risk Prediction Using Real-World Data: A Tool for Precision Medicine.贝叶斯网络在真实世界数据中的风险预测中的应用:精准医学的工具。
Value Health. 2019 Apr;22(4):439-445. doi: 10.1016/j.jval.2019.01.006. Epub 2019 Mar 15.
10
Predictive Big Data Analytics: A Study of Parkinson's Disease Using Large, Complex, Heterogeneous, Incongruent, Multi-Source and Incomplete Observations.预测性大数据分析:一项使用大规模、复杂、异构、不一致、多源和不完整观测数据对帕金森病的研究。
PLoS One. 2016 Aug 5;11(8):e0157077. doi: 10.1371/journal.pone.0157077. eCollection 2016.

引用本文的文献

1
Reflections on dynamic prediction of Alzheimer's disease: advancements in modeling longitudinal outcomes and time-to-event data.关于阿尔茨海默病动态预测的思考:纵向结果和事件发生时间数据建模的进展
BMC Med Res Methodol. 2025 Jul 17;25(1):175. doi: 10.1186/s12874-025-02618-x.

本文引用的文献

1
Review and Comparison of Computational Approaches for Joint Longitudinal and Time-to-Event Models.联合纵向和事件发生时间模型的计算方法综述与比较
Int Stat Rev. 2019 Aug;87(2):393-418. doi: 10.1111/insr.12322. Epub 2019 Apr 8.
2
On a general structure for hazard-based regression models: An application to population-based cancer research.基于危害的回归模型的一般结构:在基于人群的癌症研究中的应用。
Stat Methods Med Res. 2019 Aug;28(8):2404-2417. doi: 10.1177/0962280218782293. Epub 2018 Aug 1.
3
Landmark Models for Optimizing the Use of Repeated Measurements of Risk Factors in Electronic Health Records to Predict Future Disease Risk.
用于优化电子健康记录中风险因素重复测量以预测未来疾病风险的里程碑模型。
Am J Epidemiol. 2018 Jul 1;187(7):1530-1538. doi: 10.1093/aje/kwy018.
4
Factors associated with breast cancer recurrences or mortality and dynamic prediction of death using history of cancer recurrences: the French E3N cohort.与乳腺癌复发或死亡相关的因素以及基于癌症复发史的死亡动态预测:法国 E3N 队列研究。
BMC Cancer. 2018 Feb 9;18(1):171. doi: 10.1186/s12885-018-4076-4.
5
Up-to-date and projected estimates of survival for people with cystic fibrosis using baseline characteristics: A longitudinal study using UK patient registry data.使用基线特征对囊性纤维化患者进行最新和预计的生存估计:一项使用英国患者登记数据的纵向研究。
J Cyst Fibros. 2018 Mar;17(2):218-227. doi: 10.1016/j.jcf.2017.11.019. Epub 2018 Jan 6.
6
Dynamic prediction of outcome for patients with severe aortic stenosis: application of joint models for longitudinal and time-to-event data.重度主动脉瓣狭窄患者预后的动态预测:纵向数据和事件发生时间数据联合模型的应用
BMC Cardiovasc Disord. 2015 May 7;15:28. doi: 10.1186/s12872-015-0035-z.
7
Flexible parametric joint modelling of longitudinal and survival data.纵向和生存数据的灵活参数联合建模。
Stat Med. 2012 Dec 30;31(30):4456-71. doi: 10.1002/sim.5644. Epub 2012 Oct 4.
8
Assessing the performance of prediction models: a framework for traditional and novel measures.评估预测模型的性能:传统和新型指标的框架。
Epidemiology. 2010 Jan;21(1):128-38. doi: 10.1097/EDE.0b013e3181c30fb2.
9
Flexible maximum likelihood methods for bivariate proportional hazards models.二元比例风险模型的灵活最大似然法
Biometrics. 2003 Dec;59(4):837-48. doi: 10.1111/j.0006-341x.2003.00098.x.
10
Models for longitudinal data: a generalized estimating equation approach.纵向数据模型:一种广义估计方程方法。
Biometrics. 1988 Dec;44(4):1049-60.