Chen Yuling, Hou Shike
Institute of Disaster and Emergency Medicine, Tianjin University Tianjin China
Tianjin Key Laboratory of Disaster Medicine Technology Tianjin China.
Nanoscale Adv. 2024 Jun 11;6(16):4180-4195. doi: 10.1039/d4na00334a. eCollection 2024 Aug 6.
: rhabdomyolysis (RM) is a serious syndrome. A large area of muscle injury and dissolution induces acute kidney injury (AKI), which results in a high incidence and mortality rate. Exosomes released by mesenchymal stem cells (MSCs) have been used to treat AKI induced by rhabdomyolysis and have shown regenerative effects. However, the most serious drawbacks of these methods are poor targeting and a low enrichment rate after systemic administration. : in this study, we demonstrated that magnetic exosomes derived from bone marrow mesenchymal stem cells (BMSCs) can directly target damaged muscles rather than kidneys using an external magnetic field. : magnetic navigation exosomes reduced the dissolution of damaged muscles, greatly reduced the release of cellular contents, slowed the development of AKI. : in summary, our proposed method can overcome the shortcomings of poor targeting in traditional exosome therapy. Moreover, in the rhabdomyolysis-induced AKI model, we propose for the first time an exosome therapy mode that directly targets damaged muscles through magnetic navigation.
横纹肌溶解症（RM）是一种严重的综合征。大面积的肌肉损伤和溶解会诱发急性肾损伤（AKI），导致高发病率和死亡率。间充质干细胞（MSCs）释放的外泌体已被用于治疗由横纹肌溶解症诱发的急性肾损伤，并显示出再生作用。然而，这些方法最严重的缺点是全身给药后靶向性差和富集率低。在本研究中，我们证明了源自骨髓间充质干细胞（BMSCs）的磁性外泌体可以利用外部磁场直接靶向受损肌肉而非肾脏。磁性导航外泌体减少了受损肌肉的溶解，大大减少了细胞内容物的释放，减缓了急性肾损伤的发展。总之，我们提出的方法可以克服传统外泌体疗法靶向性差的缺点。此外，在横纹肌溶解症诱发的急性肾损伤模型中，我们首次提出了一种通过磁性导航直接靶向受损肌肉的外泌体治疗模式。
