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基于多特征方法的视网膜血管分割与分类

Retina Blood Vessels Segmentation and Classification with the Multi-featured Approach.

作者信息

Bhimavarapu Usharani

机构信息

Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India.

出版信息

J Imaging Inform Med. 2025 Feb;38(1):520-533. doi: 10.1007/s10278-024-01219-2. Epub 2024 Aug 8.

DOI:10.1007/s10278-024-01219-2
PMID:39117940
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11811302/
Abstract

Segmenting retinal blood vessels poses a significant challenge due to the irregularities inherent in small vessels. The complexity arises from the intricate task of effectively merging features at multiple levels, coupled with potential spatial information loss during successive down-sampling steps. This particularly affects the identification of small and faintly contrasting vessels. To address these challenges, we present a model tailored for automated arterial and venous (A/V) classification, complementing blood vessel segmentation. This paper presents an advanced methodology for segmenting and classifying retinal vessels using a series of sophisticated pre-processing and feature extraction techniques. The ensemble filter approach, incorporating Bilateral and Laplacian edge detectors, enhances image contrast and preserves edges. The proposed algorithm further refines the image by generating an orientation map. During the vessel extraction step, a complete convolution network processes the input image to create a detailed vessel map, enhanced by attention operations that improve modeling perception and resilience. The encoder extracts semantic features, while the Attention Module refines blood vessel depiction, resulting in highly accurate segmentation outcomes. The model was verified using the STARE dataset, which includes 400 images; the DRIVE dataset with 40 images; the HRF dataset with 45 images; and the INSPIRE-AVR dataset containing 40 images. The proposed model demonstrated superior performance across all datasets, achieving an accuracy of 97.5% on the DRIVE dataset, 99.25% on the STARE dataset, 98.33% on the INSPIREAVR dataset, and 98.67% on the HRF dataset. These results highlight the method's effectiveness in accurately segmenting and classifying retinal vessels.

摘要

由于小血管固有的不规则性,分割视网膜血管面临重大挑战。复杂性源于在多个层次上有效合并特征这一复杂任务,以及在连续下采样步骤中潜在的空间信息损失。这尤其影响小血管和对比度微弱的血管的识别。为应对这些挑战,我们提出了一种专门用于自动动脉和静脉(A/V)分类的模型,作为血管分割的补充。本文提出了一种先进的方法,使用一系列复杂的预处理和特征提取技术对视网膜血管进行分割和分类。结合双边和拉普拉斯边缘检测器的集成滤波器方法增强了图像对比度并保留了边缘。所提出的算法通过生成方向图进一步细化图像。在血管提取步骤中,一个完整的卷积网络处理输入图像以创建详细的血管图,并通过注意力操作增强,这些操作改善了建模感知和弹性。编码器提取语义特征,而注意力模块细化血管描绘,从而产生高度准确的分割结果。该模型使用STARE数据集(包括400张图像)、DRIVE数据集(40张图像)、HRF数据集(45张图像)以及包含40张图像的INSPIRE - AVR数据集进行了验证。所提出的模型在所有数据集上均表现出卓越性能,在DRIVE数据集上准确率达到97.5%,在STARE数据集上为99.25%,在INSPIRE - AVR数据集上为98.33%,在HRF数据集上为98.67%。这些结果突出了该方法在准确分割和分类视网膜血管方面的有效性。

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本文引用的文献

1
Multi-Task Segmentation and Classification Network for Artery/Vein Classification in Retina Fundus.用于眼底视网膜动静脉分类的多任务分割与分类网络
Entropy (Basel). 2023 Jul 31;25(8):1148. doi: 10.3390/e25081148.
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Deep ensemble learning for automated non-advanced AMD classification using optimized retinal layer segmentation and SD-OCT scans.基于优化的视网膜层分割和 SD-OCT 扫描的自动非晚期 AMD 分类的深度集成学习。
Comput Biol Med. 2023 Mar;154:106512. doi: 10.1016/j.compbiomed.2022.106512. Epub 2023 Jan 10.
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Dual encoder network with transformer-CNN for multi-organ segmentation.基于 Transformer-CNN 的双编码器网络的多器官分割。
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Obstructive sleep apnea, chronic obstructive pulmonary disease and hypertensive microvascular disease: a cross-sectional observational cohort study.阻塞性睡眠呼吸暂停、慢性阻塞性肺疾病和高血压性微血管病:一项横断面观察性队列研究。
Sci Rep. 2022 Aug 3;12(1):13350. doi: 10.1038/s41598-022-17481-9.
5
MFI-Net: Multiscale Feature Interaction Network for Retinal Vessel Segmentation.MFI-Net:用于视网膜血管分割的多尺度特征交互网络。
IEEE J Biomed Health Inform. 2022 Sep;26(9):4551-4562. doi: 10.1109/JBHI.2022.3182471. Epub 2022 Sep 9.
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Towards more efficient ophthalmic disease classification and lesion location via convolution transformer.通过卷积变换器实现更高效的眼科疾病分类和病变定位
Comput Methods Programs Biomed. 2022 Jun;220:106832. doi: 10.1016/j.cmpb.2022.106832. Epub 2022 Apr 27.
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Retinal Organoids and Retinal Prostheses: An Overview.视网膜类器官和视网膜假体:概述。
Int J Mol Sci. 2022 Mar 8;23(6):2922. doi: 10.3390/ijms23062922.
8
RPS-Net: An effective retinal image projection segmentation network for retinal vessels and foveal avascular zone based on OCTA data.RPS-Net:一种基于 OCTA 数据的有效视网膜图像投影分割网络,用于视网膜血管和黄斑无血管区。
Med Phys. 2022 Jun;49(6):3830-3844. doi: 10.1002/mp.15608. Epub 2022 Mar 30.
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The versatility and paradox of BMP signaling in endothelial cell behaviors and blood vessel function.BMP 信号在血管内皮细胞行为和血管功能中的多功能性和矛盾性。
Cell Mol Life Sci. 2022 Jan 19;79(2):77. doi: 10.1007/s00018-021-04033-z.
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Assessing the validity of a cross-platform retinal image segmentation tool in normal and diseased retina.评估一种跨平台视网膜图像分割工具在正常和病变视网膜中的有效性。
Sci Rep. 2021 Nov 8;11(1):21784. doi: 10.1038/s41598-021-01105-9.