Yeoh Beng San, Gewirtz Andrew T, Vijay-Kumar Matam
Department of Physiology and Pharmacology, The University of Toledo College of Medicine & Life Sciences, Toledo, Ohio.
Center for Inflammation, Immunity & Infection, Institute for Biomedical Sciences, Georgia State University, Atlanta, Georgia.
Gastro Hep Adv. 2023 Dec 9;3(3):333-335. doi: 10.1016/j.gastha.2023.12.003. eCollection 2024.
Studies in rodents suggest that inulin supplements may be carcinogenic. We present a case implicating that this risk extends to humans. A healthy male from a family lacking history of cancer had his first cancer-screening colonoscopy at age 56. No intestinal polyps/abnormalities were detected. A second colonoscopy, performed 7 years later, revealed a tumor in the cecum, with evidence of metastasis to lymph nodes. The only known change in patient's lifestyle during that seven-year period was the addition of 4g of inulin powder as a daily supplement during the last 2 years. Such inulin consumption is a plausible contributor to his disease.
对啮齿动物的研究表明，补充菊粉可能具有致癌性。我们报告了一个病例，提示这种风险也适用于人类。一名来自无癌症家族史家庭的健康男性，56岁时首次进行癌症筛查结肠镜检查，未发现肠道息肉/异常。7年后进行的第二次结肠镜检查显示盲肠有肿瘤，并伴有淋巴结转移迹象。在这7年期间，患者生活方式唯一已知的变化是在过去2年中每天添加4克菊粉粉末作为补充剂。这种菊粉的摄入很可能是导致他患病的原因。
