Cederlöf Erik, Holm Minna, Lähteenvuo Markku, Haaki Willehard, Hietala Jarmo, Häkkinen Katja, Isometsä Erkki, Jukuri Tuomas, Kajanne Risto, Kampman Olli, Kieseppä Tuula, Lahdensuo Kaisla, Lönnqvist Jouko, Männynsalo Teemu, Niemi-Pynttäri Jussi, Suokas Kimmo, Suvisaari Jaana, Tiihonen Jari, Turunen Hannu, Wegelius Asko, Veijola Juha, Palotie Aarno, Paunio Tiina
Population Health Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
Department of Psychiatry, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Schizophr Bull Open. 2022 Feb 3;3(1):sgac011. doi: 10.1093/schizbullopen/sgac011. eCollection 2022 Jan.
Characterizing sleep in patients with schizophrenia, schizoaffective disorder, bipolar disorder, and psychotic depression.
This cross-sectional questionnaire study is based on the SUPER study sample, which is part of the Stanley Global Neuropsychiatric Genomics Initiative. The study is a multicentre, nationwide Finnish study consisting of patients ( = 8 623) both in primary and specialized health care. The main measurements were sleep duration, difficulties initiating sleep, early morning awakenings, and fatigue. These results were compared with a nationally representative sample of the Finnish population from the Health 2000 survey ( = 7 167) with frequency and logistic regression analyses.
Patients had more sleep problems compared with the general population, especially young and middle-aged patients (Difficulties initiating sleep in young patients odds ratio = 12.3, 95% CI 9.8-15.4). Long sleep duration was the most deviating property of the sleep characteristics, being particularly common among young patients with schizophrenia (odds ratio = 27.9, 95% CI 22.1-35.2, 47.4% vs 3.3% prevalence). All sleep problems were associated with worse subjective health. We also conducted a latent class analysis, resulting in a cluster relatively free of sleep problems (58% of patients), an insomnia symptom cluster (26%), and a hypersomnia symptom cluster (15%).
In our sample, patients with psychotic disorders have more sleep problems-especially long sleep duration but also insomnia symptoms-compared with the general population. The patients can in a latent class analysis of their sleep symptoms be divided into groups with differing sleep profiles.
描述精神分裂症、分裂情感性障碍、双相情感障碍和伴有精神病性症状的抑郁症患者的睡眠情况。
这项横断面问卷调查研究基于斯坦利全球神经精神基因组计划的一部分——SUPER研究样本。该研究是一项芬兰全国性的多中心研究，纳入了初级和专科医疗保健机构中的患者（n = 8623）。主要测量指标为睡眠时间、入睡困难、早醒和疲劳。通过频率分析和逻辑回归分析，将这些结果与来自《健康2000》调查的具有全国代表性的芬兰人群样本（n = 7167）进行比较。
与普通人群相比，患者存在更多的睡眠问题，尤其是年轻和中年患者（年轻患者入睡困难的优势比 = 12.3，95%可信区间9.8 - 15.4）。睡眠时间长是睡眠特征中最偏离正常的属性，在患有精神分裂症的年轻患者中尤为常见（优势比 = 27.9，95%可信区间22.1 - 35.2，患病率分别为47.4%和3.3%）。所有睡眠问题都与较差的主观健康状况相关。我们还进行了潜在类别分析，结果显示存在一个相对没有睡眠问题的聚类组（58%的患者）、一个失眠症状聚类组（26%）和一个嗜睡症状聚类组（15%）。
在我们的样本中，与普通人群相比，患有精神病性障碍的患者存在更多的睡眠问题——尤其是睡眠时间长以及失眠症状。通过对患者睡眠症状的潜在类别分析，可以将他们分为具有不同睡眠特征的组。
