Grosse G
Zentralbl Bakteriol Mikrobiol Hyg A. 1985 Dec;260(4):550-65.
This animal experiment is characterized by a missing virulence of Cryptococcus neoformans strain A94 (isolated from bird manure) for the immunocompetent mouse after intraperitoneal injection and following hematogenous dissemination into all organs including the central nervous system (CNS) and by the induction of a renal failure of short duration by intramuscular injection of glycerine. In 50% of the group of 80 animals damaged in such a way ocular cryptococcosis was found in association with the selective involvement of the CNS. The involvement of the eyes was dependent on a time-limited interval between the date of infection and the date of induction of the renal failure. The partly extensive pathohistological findings in the eye, with a predominance of mycotic processes in the retina and with some cases of endophthalmitis, were found to be similar to those described in man. The animal experiment described is proposed as a model for experimental studies to resolve problems of the immunology and therapy of the ocular cryptococcosis which are of current interest.
该动物实验的特点是，从鸟粪中分离出的新型隐球菌A94菌株对免疫功能正常的小鼠腹腔注射后，经血液传播至包括中枢神经系统（CNS）在内的所有器官，其毒力缺失；以及通过肌肉注射甘油诱导短期肾功能衰竭。在80只以这种方式损伤的动物中，50%发现眼部隐球菌病，并伴有中枢神经系统的选择性受累。眼部受累取决于感染日期与肾功能衰竭诱导日期之间的时间限制间隔。眼部部分广泛的病理组织学发现，视网膜中真菌过程占优势，部分病例有眼内炎，发现与人类描述的相似。所描述的动物实验被提议作为解决当前感兴趣的眼部隐球菌病免疫和治疗问题的实验研究模型。
