脂多糖与淋巴细胞表面的结合。

The binding of LPS to the lymphocyte surface.

作者信息

Symons D B, Clarkson C A

出版信息

Immunology. 1979 Nov;38(3):503-8.

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1457832/

Abstract

Bacterial lipopolysaccharide (LPS) from Escherichia coli labelled with tritium has been used to follow the binding of LPS to lymphocytes. Binding to cells rose to a maximum 2-7 min after addition of [3H]-LPS, followed by loss of [3H]-LPS from cells, reducing to about 10% of the peak level at 20-30 min. Peripheral blood lymphocytes, mesenteric lymph node and thymus cells of the pig and CBA, C3H/He and C3H/HeJ mouse spleen cells all bound [3H]-LPS transiently at similar levels. It is concluded that this type of LPS binding cannot be solely responsible for the preferential stimulation of B cells by LPS.

摘要

用氚标记的来自大肠杆菌的细菌脂多糖（LPS）已被用于追踪LPS与淋巴细胞的结合。加入[3H]-LPS后2 - 7分钟，与细胞的结合达到最大值，随后[3H]-LPS从细胞中丢失，在20 - 30分钟时降至峰值水平的约10%。猪的外周血淋巴细胞、肠系膜淋巴结和胸腺细胞以及CBA、C3H/He和C3H/HeJ小鼠脾细胞均以相似水平短暂结合[3H]-LPS。得出的结论是，这种类型的LPS结合不能单独解释LPS对B细胞的优先刺激作用。

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本文引用的文献

1

Role of lipids in the biosynthesis of the bacterial cell envelope.脂质在细菌细胞壁生物合成中的作用。

Bacteriol Rev. 1971 Mar;35(1):14-38. doi: 10.1128/br.35.1.14-38.1971.

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Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.细菌脂多糖的结构与其在促细胞分裂和佐剂活性方面功能的关系。

Proc Natl Acad Sci U S A. 1973 Jul;70(7):2129-33. doi: 10.1073/pnas.70.7.2129.

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Biochim Biophys Acta. 1973 Mar 16;298(2):145-57. doi: 10.1016/0005-2736(73)90346-5.

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The mitogenic effect of lipopolysaccharide on bone marrow-derived mouse lymphocytes. Lipid A as the mitogenic part of the molecule.脂多糖对源自骨髓的小鼠淋巴细胞的促有丝分裂作用。脂多糖A作为该分子的促有丝分裂部分。

J Exp Med. 1973 Apr 1;137(4):943-53. doi: 10.1084/jem.137.4.943.

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PPD tuberculin--a B-cell mitogen.结核菌素纯蛋白衍生物——一种B细胞促有丝分裂原。

Nat New Biol. 1972 Dec 13;240(102):198-200. doi: 10.1038/newbio240198a0.

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A method for the selection of pig lymphocytes bearing surface immunoglobulin.一种用于选择带有表面免疫球蛋白的猪淋巴细胞的方法。

J Immunol Methods. 1975 Jun;7(2-3):251-4. doi: 10.1016/0022-1759(75)90022-8.

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Mechanism of lymphocyte activation: the binding of phytohemagglutinin to the lymphocyte surface.淋巴细胞激活机制：植物血凝素与淋巴细胞表面的结合。

Eur J Immunol. 1977 Sep;7(9):613-9. doi: 10.1002/eji.1830070907.

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Stimulation of pig lymphocytes with anti-immunoglobulin serum and mitogens.用抗免疫球蛋白血清和有丝分裂原刺激猪淋巴细胞。

Int Arch Allergy Appl Immunol. 1977;54(1):67-77. doi: 10.1159/000231809.

9

Receptor interactions on the membrane of resting and activated B cells.

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Biochim Biophys Acta. 1978 Apr 4;508(2):260-76. doi: 10.1016/0005-2736(78)90329-2.

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