细菌脂多糖的结构与其在促细胞分裂和佐剂活性方面功能的关系。
Relationship of the structure of bacterial lipopolysaccharides to its function in mitogenesis and adjuvanticity.
作者信息
Chiller J M, Skidmore B J, Morrison D C, Weigle W O
出版信息
Proc Natl Acad Sci U S A. 1973 Jul;70(7):2129-33. doi: 10.1073/pnas.70.7.2129.
Abstract
The ability of bacterial lipopolysaccharides to induce lymphocyte mitogenesis and to act as an adjuvant of antibody formation was attributable to the lipid-A region of the molecule. Measured by induction of DNA synthesis, lipid A was mitogenic for bone marrow-derived lymphocytes obtained from spleens of congenitally athymic mice but not for thymocytes obtained from thymuses of normal mice. Adjuvanticity was demonstrated by the ability of lipid A to convert a tolerogenic regimen of antigen into one eliciting an immune response and by its ability to markedly enhance the antibody response to a weak antigen.
摘要
细菌脂多糖诱导淋巴细胞有丝分裂以及作为抗体形成佐剂的能力归因于该分子的脂质A区域。通过DNA合成诱导来测定，脂质A对从先天性无胸腺小鼠脾脏获得的骨髓来源淋巴细胞具有促有丝分裂作用，但对从正常小鼠胸腺获得的胸腺细胞则无此作用。脂质A将抗原的致耐受方案转变为引发免疫应答的方案的能力以及其显著增强对弱抗原的抗体应答的能力证明了其佐剂活性。
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