Molecular Microbiology Group, Dairy Research Institute (IPLA, CSIC), Paseo Rio Linares s/n, 33300, Villaviciosa, Spain; Molecular Microbiology Group, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Food Chem Toxicol. 2024 Oct;192:114947. doi: 10.1016/j.fct.2024.114947. Epub 2024 Aug 22.
Ethylamine, ethanolamine and methylamine are biogenic amines (BA) - active metabolites that, despite having important biological functions, may accumulate at toxic concentrations in certain foods. Very little information exists on the toxicity of these BA in this context. This study provides new insights into their cytotoxicity with respect to a human intestinal epithelial cell line, as assessed using real-time cell analyzer technology. A preliminary evaluation of the cytotoxic mode of action was also performed. The present results show that only ethylamine was cytotoxic for these cells at food concentrations. These new data should help establish legal limits for these BA in foods.
乙胺、乙醇胺和甲胺是生物胺（BA）-活性代谢物，尽管具有重要的生物学功能，但在某些食物中可能会积累到有毒浓度。关于这种情况下这些 BA 的毒性，目前的信息很少。本研究使用实时细胞分析技术，对这些 BA 对人肠上皮细胞系的细胞毒性进行了新的研究。还对细胞毒性作用模式进行了初步评估。目前的结果表明，只有乙胺在食物浓度下对这些细胞具有细胞毒性。这些新数据应该有助于为这些 BA 在食品中的设定法定限量。
