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具有创纪录高灵敏度的亚波长光栅级联微环谐振器生化传感器。

Subwavelength Grating Cascaded Microring Resonator Biochemical Sensors with Record-High Sensitivity.

作者信息

Cheng Weiqing, Ye Shengwei, Yuan Bocheng, Marsh John H, Hou Lianping

机构信息

James Watt School of Engineering, University of Glasgow, Glasgow G12 8QQ, U.K.

出版信息

ACS Photonics. 2024 Aug 1;11(8):3343-3350. doi: 10.1021/acsphotonics.4c00778. eCollection 2024 Aug 21.

Abstract

Photonic integrated circuit biochemical and biomedical sensors show promising applications in medical diagnosis, food security, healthcare, and environmental monitoring. Silicon-on-insulator subwavelength grating waveguides and cascaded microring resonator structures enhance photon-analyte interaction, offering superior sensing performance (higher sensitivity with lower limit of detection and larger free spectral range) compared to traditional strip and slot waveguide microring resonator structures. In this study, we design, simulate, and experimentally demonstrate a novel and compact biochemical sensor integrating subwavelength grating cascaded microring resonators and multibox subwavelength grating straight waveguides on a silicon-on-insulator platform. We achieve a record-high refractive index sensitivity of 810 nm/RIU with a limit of detection value of 2.04 × 10 RIU. The measured concentration sensitivity for sodium chloride solutions is 1430 pm/% with a limit of detection of 0.04%. The free spectral range is 35.8 nm, and the measured factor is 1.9 × 10. By combining the advantages of cascaded microring resonators with those subwavelength gratings, our sensor offers unprecedented sensitivity for biochemical sensing applications, promising significant enhancements in healthcare diagnostics and environmental monitoring systems.

摘要

光子集成电路生化和生物医学传感器在医学诊断、食品安全、医疗保健和环境监测等领域显示出广阔的应用前景。绝缘体上硅亚波长光栅波导和级联微环谐振器结构增强了光子与分析物的相互作用,与传统的条形和槽形波导微环谐振器结构相比,具有卓越的传感性能(更高的灵敏度、更低的检测限和更大的自由光谱范围)。在本研究中,我们在绝缘体上硅平台上设计、模拟并通过实验证明了一种新型紧凑型生化传感器,该传感器集成了亚波长光栅级联微环谐振器和多盒亚波长光栅直波导。我们实现了创纪录的810 nm/RIU的高折射率灵敏度,检测限值为2.04×10 RIU。氯化钠溶液的测量浓度灵敏度为1430 pm/%,检测限为0.04%。自由光谱范围为35.8 nm,测量品质因数为1.9×10。通过结合级联微环谐振器和亚波长光栅的优点,我们的传感器为生化传感应用提供了前所未有的灵敏度,有望显著提升医疗诊断和环境监测系统的性能。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4782/11342415/738f7e0535e8/ph4c00778_0001.jpg

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