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2型糖尿病患者糖尿病视网膜病变的预测因素:一项横断面研究。

Predictors of Diabetic Retinopathy in Type 2 Diabetes: A Cross-Sectional Study.

作者信息

Ivanescu Adriana, Popescu Simona, Ivanescu Radu, Potra Monica, Timar Romulus

机构信息

Second Department of Internal Medicine, "Victor Babes" University of Medicine and Pharmacy, 300041 Timisoara, Romania.

Opticlass Ophtalmology Clinic, 300012 Timisoara, Romania.

出版信息

Biomedicines. 2024 Aug 19;12(8):1889. doi: 10.3390/biomedicines12081889.

Abstract

BACKGROUND

Type 2 diabetes mellitus (T2DM) represents one of the most impacting health issues of the modern era, as it is associated with an extensive range of comorbidities. Diabetic retinopathy (DR) is one the utmost severe diabetes complications as it is one of the major causes of vision loss among these patients. Our present research aims to evaluate the most frequent risk factors related to the occurrence of DR in T2DM patients.

METHOD

This study consisted of a research group of 302 participants, priorly diagnosed with T2DM, that were evaluated for the most important risk factors related to the occurrence of DR.

RESULTS

Patients had a median age of 64 years, 48% of them being women, with a 12-year median duration of DM and presenting a deficient glycaemic control echoed by a median HbA1C value of 7.5%. From the total number of participants, the total prevalence of DR in different stages of severity was 34.8% with a 95% CI. Statistically significant values were found regarding DM duration ( = 0.007), HbA1c > 7.2% ( = 0.001) and patients aged over 67 years ( = 0.0035), all these parameters being directly linked to DR.

CONCLUSIONS

Older patients with T2DM that have a longer disease duration and simultaneous comorbidities present a higher risk of DR development, consequently a stringent management of these pathologies is needed.

摘要

背景

2型糖尿病(T2DM)是现代社会中对健康影响最大的问题之一,因为它与多种合并症相关。糖尿病视网膜病变(DR)是最严重的糖尿病并发症之一,是这些患者视力丧失的主要原因之一。我们目前的研究旨在评估T2DM患者中与DR发生相关的最常见危险因素。

方法

本研究包括一个由302名参与者组成的研究组,这些参与者先前已被诊断为T2DM,对其进行了与DR发生相关的最重要危险因素的评估。

结果

患者的中位年龄为64岁,其中48%为女性,糖尿病的中位病程为12年,血糖控制不佳,中位糖化血红蛋白(HbA1C)值为7.5%反映了这一点。在所有参与者中,不同严重程度阶段DR的总患病率为34.8%,95%置信区间。发现糖尿病病程(P = 0.007)、HbA1c>7.2%(P = 0.001)和67岁以上患者(P = 0.0035)具有统计学显著意义,所有这些参数都与DR直接相关。

结论

患有T2DM且病程较长并伴有合并症的老年患者发生DR的风险较高,因此需要对这些病症进行严格管理。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/24c2/11352174/909c0e42b55d/biomedicines-12-01889-g001.jpg

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