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1
alpha-Aminoadipate as a primary nitrogen source for Saccharomyces cerevisiae mutants.α-氨基己二酸作为酿酒酵母突变体的主要氮源。
J Bacteriol. 1985 May;162(2):579-83. doi: 10.1128/jb.162.2.579-583.1985.
2
alpha-Aminoadipate pathway for the biosynthesis of lysine in lower eukaryotes.低等真核生物中赖氨酸生物合成的α-氨基己二酸途径。
Crit Rev Microbiol. 1985;12(2):131-51. doi: 10.3109/10408418509104427.
3
Selection of lys2 Mutants of the Yeast SACCHAROMYCES CEREVISIAE by the Utilization of alpha-AMINOADIPATE.利用 α-氨基己二酸筛选酵母 SACCHAROMYCES CEREVISIAE 的 lys2 突变株。
Genetics. 1979 Sep;93(1):51-65. doi: 10.1093/genetics/93.1.51.
4
Lysine biosynthesis in Saccharomyces cerevisiae: mechanism of alpha-aminoadipate reductase (Lys2) involves posttranslational phosphopantetheinylation by Lys5.酿酒酵母中的赖氨酸生物合成：α-氨基己二酸还原酶（Lys2）的机制涉及由Lys5进行的翻译后磷酸泛酰巯基乙胺化。
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Properties of revertants of lys2 and lys5 mutants as well as alpha-aminoadipate-semialdehyde dehydrogenase from Saccharomyces cerevisiae.酿酒酵母lys2和lys5突变体回复突变株以及α-氨基己二酸半醛脱氢酶的特性
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Growth inhibition by alpha-aminoadipate and reversal of the effect by specific amino acid supplements in Saccharomyces cerevisiae.α-氨基己二酸对酿酒酵母的生长抑制作用以及特定氨基酸补充剂对该作用的逆转
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Molecular analysis of the LYS2 gene of Candida albicans: homology to peptide antibiotic synthetases and the regulation of the alpha-aminoadipate reductase.白色念珠菌LYS2基因的分子分析：与肽抗生素合成酶的同源性及α-氨基己二酸还原酶的调控
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Physical and biochemical characterization of the cloned LYS5 gene required for alpha-aminoadipate reductase activity in the lysine biosynthetic pathway of Saccharomyces cerevisiae.酿酒酵母赖氨酸生物合成途径中α-氨基己二酸还原酶活性所需的克隆LYS5基因的物理和生化特性
Curr Genet. 1992 Jan;21(1):13-6. doi: 10.1007/BF00318647.

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本文引用的文献

1
Selection of lys2 Mutants of the Yeast SACCHAROMYCES CEREVISIAE by the Utilization of alpha-AMINOADIPATE.利用 α-氨基己二酸筛选酵母 SACCHAROMYCES CEREVISIAE 的 lys2 突变株。
Genetics. 1979 Sep;93(1):51-65. doi: 10.1093/genetics/93.1.51.
2
HEREDITARY DEFECTS IN GALACTOSE METABOLISM IN ESCHERICHIA COLI MUTANTS, II. GALACTOSE-INDUCED SENSITIVITY.大肠杆菌突变体中半乳糖代谢的遗传性缺陷，II. 半乳糖诱导的敏感性
Proc Natl Acad Sci U S A. 1959 Dec;45(12):1786-91. doi: 10.1073/pnas.45.12.1786.
3
SACCHAROPINE, AN INTERMEDIATE OF THE AMINOADIPIC ACID PATHWAY OF LYSINE BIOSYNTHESIS. II. STUDIES IN SACCHAROMYCES CEREVISEAE.酵母氨酸，赖氨酸生物合成氨基己二酸途径的一种中间体。II. 酿酒酵母中的研究。
J Biol Chem. 1965 Jun;240:2531-6.
4
ENZYMATIC EXPRESSION AND GENETIC LINKAGE OF GENES CONTROLLING GALACTOSE UTILIZATION IN SACCHAROMYCES.酿酒酵母中控制半乳糖利用的基因的酶表达与遗传连锁
Genetics. 1964 May;49(5):837-44. doi: 10.1093/genetics/49.5.837.
5
Interference with growth of certain Escherichia coli mutants by galactose.半乳糖对某些大肠杆菌突变体生长的干扰
Biochim Biophys Acta. 1958 Nov;30(2):298-302. doi: 10.1016/0006-3002(58)90054-4.
6
Growth inhibition by alpha-aminoadipate and reversal of the effect by specific amino acid supplements in Saccharomyces cerevisiae.α-氨基己二酸对酿酒酵母的生长抑制作用以及特定氨基酸补充剂对该作用的逆转
J Bacteriol. 1982 Nov;152(2):874-9. doi: 10.1128/jb.152.2.874-879.1982.
7
Two unlinked lysine genes (LYS9 and LYS14) are required for the synthesis of saccharopine reductase in Saccharomyces cerevisiae.酿酒酵母中合成酵母氨酸还原酶需要两个不连锁的赖氨酸基因（LYS9和LYS14）。
J Bacteriol. 1984 Jul;159(1):429-32. doi: 10.1128/jb.159.1.429-432.1984.
8
Ammonia regulation of amino acid permeases in Saccharomyces cerevisiae.酿酒酵母中氨基酸通透酶的氨调节
Mol Cell Biol. 1983 Apr;3(4):672-83. doi: 10.1128/mcb.3.4.672-683.1983.
9
Regulation of pyrimidine biosynthesis in Saccharomyces cerevisiae.酿酒酵母中嘧啶生物合成的调控
J Bacteriol. 1968 Mar;95(3):824-32. doi: 10.1128/jb.95.3.824-832.1968.
10
Relationship among the genes, enzymes, and intermediates of the biosynthetic pathway of lysine in Saccharomyces.酿酒酵母中赖氨酸生物合成途径的基因、酶和中间产物之间的关系。
Mol Gen Genet. 1972;115(1):26-30. doi: 10.1007/BF00272214.

α-氨基己二酸作为酿酒酵母突变体的主要氮源。

alpha-Aminoadipate as a primary nitrogen source for Saccharomyces cerevisiae mutants.

作者信息

Zaret K S, Sherman F

出版信息

J Bacteriol. 1985 May;162(2):579-83. doi: 10.1128/jb.162.2.579-583.1985.

DOI:10.1128/jb.162.2.579-583.1985
PMID:3921525
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC218887/
Abstract

In contrast to wild-type strains of the yeast Saccharomyces cerevisiae, lys2 and lys5 mutants are able to utilize alpha-aminoadipate as a primary source of nitrogen. Chattoo et al. (B. B. Chattoo, F. Sherman, D. A. Azubalis, T. A. Fjellstedt, D. Mehnert, and M. Ogur, Genetics 93:51-65, 1979) relied on this difference in the effective utilization of alpha-aminoadipate to develop a procedure for directly selecting lys2 and lys5 mutants. In this study we used a range of mutant strains and various media to determine why normal strains are unable to utilize alpha-aminoadipate as a nitrogen source. Our results demonstrate that the anabolism of high levels of alpha-aminoadipate through the biosynthetic pathway of lysine results in the accumulation of a toxic intermediate and, furthermore, that lys2 and lys5 mutants contain blocks leading to the formation of this intermediate.

摘要

与酿酒酵母的野生型菌株相比，lys2和lys5突变体能够利用α-氨基己二酸作为主要氮源。Chattoo等人（B. B. Chattoo、F. Sherman、D. A. Azubalis、T. A. Fjellstedt、D. Mehnert和M. Ogur，《遗传学》93:51 - 65，1979）利用α-氨基己二酸有效利用方面的这种差异，开发了一种直接筛选lys2和lys5突变体的方法。在本研究中，我们使用了一系列突变菌株和各种培养基，以确定正常菌株无法利用α-氨基己二酸作为氮源的原因。我们的结果表明，通过赖氨酸生物合成途径进行的高水平α-氨基己二酸的合成代谢会导致一种有毒中间体的积累，此外，lys2和lys5突变体含有导致该中间体形成的阻断。