Sarnesto A, Ranta S, Väänänen P, Mäkelä O
Scand J Immunol. 1985 Mar;21(3):275-82. doi: 10.1111/j.1365-3083.1985.tb01430.x.
The proportions of six immunoglobulin isotypes (IgA, IgM, IgG1, IgG2, IgG3, and IgG4) in rubella antibody responses were quantified in 40 serum samples (20 patients). The first sample from each patient was taken during the first days of the illness, and the second sample 10 +/- 1 days later. A tenfold average increase in antibody concentration was observed between the first and the second sample. IgM was the predominant isotype in the first sample (average, 73% of all antibodies), followed by IgG1 (19%). IgA and IgG3 antibodies were detected in only a few of the first samples, and IgG2 or IgG4 in none. In the second samples IgG1 was the predominant antibody isotype (average, 59%). Next came IgM (23%), followed by IgA (8%) and IgG3 (3%). No IgG2 or IgG4 antibodies were detected. Although the proportion of IgM antibodies was lower in the second than in the first samples, their concentration increased in all patients (the average factor was 7). The kinetics of the IgA response was irregular. In some patients there was a strong (up to 90-fold) increase in IgA antibodies, but in two patients a small drop was detected. The kappa- to lambda-chain ratio of rubella antibodies appears to be close to the expected 2:1. It decreased in some patients during the 10 days and increased in others.
在40份血清样本（20名患者）中对风疹抗体反应中六种免疫球蛋白同种型（IgA、IgM、IgG1、IgG2、IgG3和IgG4）的比例进行了定量分析。每位患者的第一份样本在疾病初期采集，第二份样本在10±1天后采集。在第一份和第二份样本之间观察到抗体浓度平均增加了10倍。IgM是第一份样本中的主要同种型（平均占所有抗体的73%），其次是IgG1（19%）。仅在少数第一份样本中检测到IgA和IgG3抗体，未检测到IgG2或IgG4抗体。在第二份样本中，IgG1是主要的抗体同种型（平均占59%）。其次是IgM（23%），然后是IgA（8%）和IgG3（3%）。未检测到IgG2或IgG4抗体。虽然第二份样本中IgM抗体的比例低于第一份样本，但其浓度在所有患者中均有所增加（平均系数为7）。IgA反应的动力学不规则。在一些患者中，IgA抗体有强烈增加（高达90倍），但在两名患者中检测到少量下降。风疹抗体的κ链与λ链比例似乎接近预期的2:1。在10天内，一些患者的该比例下降，而另一些患者则上升。
