远紫外线C、紫外线C和紫外线B照射对……的敏感性分析
Sensitivity Analysis of , and by Irradiation with Far-UVC, UVC, and UVB.
作者信息
Gierke Anna-Maria, Hessling Martin
机构信息
Institute of Medical Engineering and Mechatronics, Ulm University of Applied Sciences, Ulm, Germany.
出版信息
Pathog Immun. 2024 Aug 21;9(2):135-151. doi: 10.20411/pai.v9i2.723. eCollection 2024.
BACKGROUND
The World Health Organization has published a list of pathogenic fungi with prior-itizing groups and calls for research and development of antifungal measures, with belonging to the group with high priority.
METHODS
The photosensitivity towards short wavelength ultraviolet irradiation (Far-UVC, UVC, and UVB) was investigated and compared to other yeasts () and a mold (). The observed 1-log reduction doses were compared to literature values of other representatives of the genus , but also with and .
RESULTS
For the determined 1-log reduction doses, an increase with higher wavelengths was observed. A 1-log reduction dose of 4.3 mJ/cm was determined for when irradiated at 222 nm, a dose of 6.1 mJ/cm at 254 nm and a 1-log reduction dose of 51.3 mJ/cm was required when irradiated with UVB.
CONCLUSIONS
It was observed that is a possible surrogate for for irradiation with Far-UVC and UVB due to close 1-log reduction doses. No surrogate suitability was verified for in relation to and for irradiation with a wavelength of 254 nm and for at 222 nm.
背景
世界卫生组织已公布了一份具有优先排序组的致病真菌清单，并呼吁开展抗真菌措施的研究与开发，[具体真菌名称]属于高优先级组。
方法
研究了[具体真菌名称]对短波长紫外线照射（远紫外线C、紫外线C和紫外线B）的光敏性，并与其他酵母（[具体酵母名称]）和一种霉菌（[具体霉菌名称]）进行比较。将观察到的1个对数减少剂量与[真菌属名称]其他代表的文献值进行比较，同时也与[其他比较对象名称1]和[其他比较对象名称2]进行比较。
结果
对于确定的1个对数减少剂量，观察到随着波长增加而增加。当在222nm照射时，[具体真菌名称]的1个对数减少剂量为4.3mJ/cm²，在254nm时为6.1mJ/cm²，用紫外线B照射时需要51.3mJ/cm²的1个对数减少剂量。
结论
观察到由于1个对数减少剂量相近，[具体真菌名称]在用远紫外线C和紫外线B照射时可能是[目标真菌名称]的替代物。对于波长为254nm的照射以及在222nm时的[具体真菌名称]，未验证[替代真菌名称]相对于[目标真菌名称]的替代适用性。
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