抗真菌活性实验室评估中的问题。
Problems in the laboratory assessment of antifungal activity.
作者信息
Odds F C
出版信息
Postgrad Med J. 1979 Sep;55(647):677-80. doi: 10.1136/pgmj.55.647.677.
Abstract
The end points of tube dilution tests for minimal inhibitory concentrations of miconazole and flucytosine against Candida albicans were difficult to evaluate because partial inhibition was noted over a wide range of antifungal concentrations. This problem was not encountered with amphotericin B. Partial inhibition of Candida arose because of reductions in yeast growth rate and of cell yield. Different sizes of yeast inocula were differentially inhibited by the same concentration of antifungal agent. An in vitro apparatus was described in which miconazole formulated as commercial creams, pessaries and medicated tampons for intravaginal application could be assessed for its inhibitory action in vitro.
摘要
测定咪康唑和氟胞嘧啶对白色念珠菌的最低抑菌浓度的试管稀释试验终点难以评估，因为在广泛的抗真菌浓度范围内均观察到部分抑制作用。两性霉素B未出现此问题。念珠菌的部分抑制是由于酵母生长速率和细胞产量降低所致。相同浓度的抗真菌剂对不同大小的酵母接种物有不同程度的抑制作用。本文描述了一种体外装置，可用于评估制成用于阴道给药的市售乳膏、阴道栓剂和药棉的咪康唑的体外抑制作用。
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本文引用的文献
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Antimicrob Agents Chemother. 1974 Apr;5(4):420-5. doi: 10.1128/AAC.5.4.420.
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Obfuscation of the activity of antifungal antimicrobics by culture media.培养基对抗真菌抗菌剂活性的干扰。
J Infect Dis. 1972 Oct;126(4):353-61. doi: 10.1093/infdis/126.4.353.
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Antimicrobial susceptibility testing of yeasts: a turbidimetric technique independent of inoculum size.酵母的药敏试验：一种与接种量无关的比浊法技术。
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