Innovative prevention and control of coccidiosis: targeting sporogony for new control agent development.

Coccidiosis is one of the most significant diseases affecting the poultry industry, with recent estimates indicating that it causes annual losses exceeding £10 billion globally. Increasing concerns over drug residues and resistance have elevated the importance of safe and effective vaccines as the primary method for controlling coccidiosis and other animal diseases. However, current commercial live vaccines for coccidiosis can negatively impact the feed conversion rates of young broilers and induce subclinical symptoms of coccidiosis, limiting their widespread adoption. Eimeria species, the causative agents of coccidiosis, exhibit unique biological characteristics. Their life cycle involves 2 or more generations of schizogony and 1 generation of gametogony within the host, followed by sporogony in a suitable external environment. Sporogony is crucial for Eimeria oocysts to become infectious and propagate within the host. Focusing on the sporogony process of Eimeria presents a promising approach to overcoming technical challenges in the efficient control of coccidiosis, addressing the urgent need for sustainable and healthy farming practices. This paper systematically reviews existing control strategies for coccidiosis, identifies current challenges, and emphasizes the research progress and future directions in developing control agents targeting sporogony. The goal is to provide guidance for the formulation of scientific prevention and control measures for coccidiosis.