莱姆病地方性疫源地的鉴定：从野生啮齿动物和蜱（变异革蜱）中分离出伯氏疏螺旋体。
Identification of endemic foci of Lyme disease: isolation of Borrelia burgdorferi from feral rodents and ticks (Dermacentor variabilis).
作者信息
Anderson J F, Johnson R C, Magnarelli L A, Hyde F W
出版信息
J Clin Microbiol. 1985 Jul;22(1):36-8. doi: 10.1128/jcm.22.1.36-38.1985.
Abstract
Borrelia burgdorferi, the etiological agent of Lyme disease, was isolated from the blood, kidneys, spleens, eyes, or livers of white-footed mice (Peromyscus leucopus) (n = 19 of 22) and from the blood, kidneys, or spleens of eastern chipmunks (Tamias striatus) (n = 2 of 2) captured at three foci for Lyme disease in eastern Connecticut. These bacteria were cultured most frequently from spleens (n = 19) and kidneys (n = 15). B. burgdorferi persisted in one mouse for at least 60 days. One spirochetemic mouse had infected Ixodes dammini and Dermacentor variabilis larvae attached, suggesting that these ticks may have acquired spirochetes from the host. Spirochetes isolated from P. leucopus, T. striatus, and D. variabilis larvae were serologically and genetically indistinguishable from reference B. burgdorferi isolates. We conclude that isolation of spirochetes from feral rodents is a method for identifying endemic areas of Lyme disease.
摘要
莱姆病的病原体伯氏疏螺旋体，是从在康涅狄格州东部三个莱姆病疫源地捕获的白足鼠（白足鼠属）的血液、肾脏、脾脏、眼睛或肝脏（22只中有19只）以及东部花栗鼠（条纹金花鼠）的血液、肾脏或脾脏（2只中有2只）中分离出来的。这些细菌最常从脾脏（19例）和肾脏（15例）中培养出来。伯氏疏螺旋体在一只小鼠体内持续存在至少60天。一只发生螺旋体血症的小鼠身上附着有感染性的达氏硬蜱和变异革蜱幼虫，这表明这些蜱可能从宿主身上获得了螺旋体。从白足鼠、条纹金花鼠和达氏硬蜱幼虫中分离出的螺旋体在血清学和遗传学上与参考伯氏疏螺旋体分离株无法区分。我们得出结论，从野生啮齿动物中分离螺旋体是一种识别莱姆病流行区域的方法。
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本文引用的文献
1
Lyme disease-a tick-borne spirochetosis?莱姆病——一种蜱传播的螺旋体病？
Science. 1982 Jun 18;216(4552):1317-9. doi: 10.1126/science.7043737.
2
Spirochetes in Ixodes dammini and mammals from Connecticut.来自康涅狄格州的达氏硬蜱和哺乳动物体内的螺旋体。
Am J Trop Med Hyg. 1983 Jul;32(4):818-24. doi: 10.4269/ajtmh.1983.32.818.
3
Ticks and Lyme disease in the United States.美国的蜱虫与莱姆病
Ann Intern Med. 1983 Jul;99(1):121. doi: 10.7326/0003-4819-99-1-121.
4
Natural Distribution of the Ixodes dammini spirochete.达米尼硬蜱螺旋体的自然分布。
Science. 1983 Apr 15;220(4594):321-2. doi: 10.1126/science.6836274.
5
Spirochetes isolated from the blood of two patients with Lyme disease.从两名莱姆病患者血液中分离出的螺旋体。
N Engl J Med. 1983 Mar 31;308(13):740-2. doi: 10.1056/NEJM198303313081302.
6
The spirochetal etiology of Lyme disease.莱姆病的螺旋体病因
N Engl J Med. 1983 Mar 31;308(13):733-40. doi: 10.1056/NEJM198303313081301.
7
Spirochete-associated arthritis (Lyme disease) in a dog.一只狗的螺旋体相关性关节炎（莱姆病）。
J Am Vet Med Assoc. 1984 Jul 15;185(2):219-20.
8
Antibodies to spirochetes in white-tailed deer and prevalence of infected ticks from foci of Lyme disease in Connecticut.康涅狄格州白尾鹿体内螺旋体抗体及莱姆病疫源地感染蜱虫的患病率
J Wildl Dis. 1984 Jan;20(1):21-6. doi: 10.7589/0090-3558-20.1.21.
9
Amblyomma americanum: a potential vector of Lyme disease in New Jersey.美洲钝眼蜱：新泽西州莱姆病的潜在传播媒介。
Science. 1984 May 11;224(4649):601-3. doi: 10.1126/science.6710158.
10
Parasitism by Ixodes dammini (Acari: Ixodidae) and antibodies to spirochetes in mammals at Lyme disease foci in Connecticut, USA.美国康涅狄格州莱姆病疫源地中，达米尼硬蜱（蜱螨亚纲：硬蜱科）的寄生情况及哺乳动物中抗螺旋体抗体情况
J Med Entomol. 1984 Jan 26;21(1):52-7. doi: 10.1093/jmedent/21.1.52.
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