将药物递送到大脑：有机纳米颗粒递药系统在协助药物穿越血脑屏障方面的进展和前景。

Getting drugs to the brain: advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood-brain barrier.

机构信息

Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science, College of Chemistry and Chemical Engineering, Central South University, Changsha, 410083, China.

College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen, 518118, China.

出版信息

J Mater Chem B. 2022 Nov 23;10(45):9314-9333. doi: 10.1039/d2tb01440h.

DOI:10.1039/d2tb01440h

PMID:36349976

Abstract

The blood-brain barrier (BBB) plays an irreplaceable role in protecting the central nervous system (CNS) from bloodborne pathogens. However, the BBB complicates the treatment of CNS diseases because it prevents almost all therapeutic drugs from getting into the CNS. With the growing understanding of the physiological characteristics of the BBB and the development of nanotechnology, nanomaterial-based drug delivery systems have become promising tools for delivering drugs across the BBB to the CNS. Herein, we systematically summarize the recent progress in organic-nanoparticle delivery systems for treating CNS diseases and evaluate their mechanisms in overcoming the BBB with the aim to provide a comprehensive understanding of the advantages, disadvantages, and challenges of organic nanoparticles in delivering drugs across the BBB. This review may inspire new research ideas and directions for applying nanotechnology to treat CNS diseases.

摘要

血脑屏障（BBB）在保护中枢神经系统（CNS）免受血源性病原体侵害方面发挥着不可替代的作用。然而，由于 BBB 几乎阻止了所有治疗药物进入 CNS，这使得 CNS 疾病的治疗变得复杂。随着人们对 BBB 生理特性的认识不断加深和纳米技术的发展，基于纳米材料的药物传递系统已成为将药物递送至 CNS 以治疗 CNS 疾病的有前途的工具。在此，我们系统地总结了用于治疗 CNS 疾病的有机-纳米粒子传递系统的最新进展，并评估了它们克服 BBB 的机制，旨在全面了解有机纳米粒子在将药物递送至 BBB 方面的优缺点和挑战。这篇综述可能会为应用纳米技术治疗 CNS 疾病提供新的研究思路和方向。