Department of Medical Biology and Biochemistry, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland.
Student Research Club of Medical Biology and Biochemistry, Department of Medical Biology and Biochemistry, Faculty of Medicine, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Torun, 87-100 Torun, Poland.
Int J Mol Sci. 2024 Aug 29;25(17):9409. doi: 10.3390/ijms25179409.
Oxidative stress and its relationship to fertility and reproduction is a topic of interest in medicine, especially in the context of the effects of trace elements and micronutrients. Oxidative stress occurs when there is an excess of free radicals in the body, which can lead to cell and tissue damage. Free radicals are reactive oxygen species (ROS) that can be formed as a result of normal metabolic processes, as well as under the influence of external factors such as environmental pollution, UV radiation, and diet. Oxidative stress has a significant impact on fertility. In men, it can lead to DNA damage in sperm, which can result in reduced semen quality, reduced sperm motility and increased numbers of defective sperm, and free radical damage to sperm cell membranes causing a reduction in the number of available sperm. In women, oxidative stress can affect the quality of female reproductive cells, which can lead to problems with their maturation and with embryo implantation in the uterus and can also affect ovarian function and disrupt hormonal regulation of the menstrual cycle. A proper balance of trace elements and micronutrients is key to protecting against oxidative stress and maintaining reproductive health. Supplementation with appropriate elements such as zinc, selenium, copper, manganese, chromium, and iron can help reduce oxidative stress and improve fertility. This work discusses the effects of selected elements on oxidative stress parameters specifically in terms of fertility and reproduction.
氧化应激及其与生育和生殖的关系是医学领域的一个研究课题，特别是在微量元素和微量营养素的影响方面。当体内自由基过多时，就会发生氧化应激，这可能导致细胞和组织损伤。自由基是活性氧（ROS），它可以通过正常的代谢过程形成，也可以在环境污染、紫外线辐射和饮食等外部因素的影响下形成。氧化应激对生育能力有重大影响。在男性中，它可能导致精子中的 DNA 损伤，从而导致精液质量下降、精子活力降低和畸形精子数量增加，以及精子细胞膜的自由基损伤导致精子数量减少。在女性中，氧化应激会影响女性生殖细胞的质量，从而导致其成熟过程中出现问题，并且可能影响卵巢功能和扰乱月经周期的激素调节。微量元素和微量营养素的适当平衡是防止氧化应激和维持生殖健康的关键。补充适当的元素，如锌、硒、铜、锰、铬和铁，可以帮助减轻氧化应激并提高生育能力。本研究讨论了特定元素对氧化应激参数的影响，特别是在生育和生殖方面。
