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印度尼西亚无刺蜜蜂蜂胶的特性及基于地域和物种的代谢组学特性研究。

Characteristics of Indonesian Stingless Bee Propolis and Study of Metabolomic Properties Based on Region and Species.

机构信息

Faculty of Pharmacy, Universitas Indonesia, Cluster of Health Sciences Building, Depok 16424, West Java, Indonesia.

National Metabolomics Collaborative Research Center, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok 16424, West Java, Indonesia.

出版信息

Molecules. 2024 Aug 26;29(17):4037. doi: 10.3390/molecules29174037.

DOI:10.3390/molecules29174037
PMID:39274885
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11396675/
Abstract

The chemical compounds found in propolis vary according to plant sources, species, and geographical regions. To date, Indonesian propolis has not yet become standardized in terms of its chemical constituents. Thus, this study aimed to identify the presence of marker compounds and determine whether different classes of Indonesian propolis exist. In this study, yields, total polyphenol content (TPC), total flavonoid content (TFC), and antioxidants were measured. Identification of chemical compounds was carried out with Fourier-transform infrared (FTIR) spectroscopy and liquid chromatography-tandem mass spectrometry (LC-MS/MS). Metaboanalyst 6.0 was employed in conducting principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) using the results of the FTIR and LC-MS/MS. The propolis with the highest TFC, TPC, and antioxidant activity was from North Sumatra. The results of propolis compound mapping based on region with discriminant analysis revealed that types of propolis from Java have similar characteristics. Then, based on species, the types of propolis from and have special characteristics; the samples from these species can be grouped according to similar characteristics. In conclusion, 10 potential marker compounds were identified in Indonesian propolis, enabling regional and species-specific varieties of Indonesian propolis to be classified based on chemical composition mapping.

摘要

蜂胶中含有的化合物因植物来源、种类和地理位置而异。迄今为止，印度尼西亚蜂胶在化学成分方面尚未标准化。因此，本研究旨在确定标记化合物的存在，并确定是否存在不同种类的印度尼西亚蜂胶。在这项研究中，测量了产率、总多酚含量（TPC）、总黄酮含量（TFC）和抗氧化剂。采用傅里叶变换红外（FTIR）光谱和液相色谱-串联质谱（LC-MS/MS）对化学化合物进行鉴定。采用 Metaboanalyst 6.0 软件对 FTIR 和 LC-MS/MS 的结果进行主成分分析（PCA）和偏最小二乘判别分析（PLS-DA）。来自北苏门答腊的蜂胶具有最高的 TFC、TPC 和抗氧化活性。基于区域的蜂胶化合物图谱分析与判别分析的结果表明，爪哇蜂胶的类型具有相似的特征。然后，根据物种，来自 和 的蜂胶具有特殊特征；这些物种的样本可以根据相似的特征进行分组。总之，在印度尼西亚蜂胶中鉴定出 10 种潜在的标记化合物，可根据化学成分图谱对印度尼西亚蜂胶的地区和物种差异进行分类。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/368a12461268/molecules-29-04037-g013.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/d95057212d97/molecules-29-04037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/589c7f5c4c40/molecules-29-04037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/c70ce9f2a335/molecules-29-04037-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/a7f63d10a807/molecules-29-04037-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/b36c7b90e6d9/molecules-29-04037-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/1363d0a6dd38/molecules-29-04037-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/368a12461268/molecules-29-04037-g013.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/68da2f4d37ed/molecules-29-04037-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/a5d03850e793/molecules-29-04037-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/69c1dd8fb54a/molecules-29-04037-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/8b6f8a37fe90/molecules-29-04037-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/1b7d612158b7/molecules-29-04037-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/28ab45d10788/molecules-29-04037-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/d95057212d97/molecules-29-04037-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/589c7f5c4c40/molecules-29-04037-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/c70ce9f2a335/molecules-29-04037-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/a7f63d10a807/molecules-29-04037-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/b36c7b90e6d9/molecules-29-04037-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/1363d0a6dd38/molecules-29-04037-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4d29/11396675/368a12461268/molecules-29-04037-g013.jpg

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