Department of Biology, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
Student Research Committee, Shahrekord University of Medical Sciences, Shahrekord, Iran.
Funct Integr Genomics. 2024 Sep 19;24(5):165. doi: 10.1007/s10142-024-01444-6.
Cardiovascular diseases (CVDs) a major contributor to global mortality rates, with a steadily rising prevalence observed across the world. Understanding the molecular mechanisms that underlie the signaling pathways implicated in the pathogenesis of CVDs represents a salient and advantageous avenue toward the development of precision and targeted therapeutics. A recent development in CVDs research is the discovery of long non-coding RNAs (lncRNAs), which are now understood to have crucial roles in the onset and development of several pathophysiological processes. The distinct expression patterns exhibited by lncRNAs in various CVDs contexts, present a significant opportunity for their utilization as both biomarkers and targets for therapeutic intervention. Among the various identified lncRNAs, HOX antisense intergenic RNA (HOTAIR) functions as signaling molecules that are significantly implicated in the pathogenesis of cardiovascular disorders in response to risk factors. HOTAIR has been observed to circulate within the bloodstream and possesses an integral epigenetic regulatory function in the transcriptional pathways of many diseases. Recent studies have suggested that HOTAIR offers promise as a biomarker for the detection and treatment of CVDs. The investigation on HOTAIR's role in CVDs, however, is still in its early phases. The goal of the current study is to give a thorough overview of recent developments in the field of analyzing the molecular mechanism of HOTAIR in controlling the pathophysiological processes of CVDs as well as its possible therapeutic uses.
心血管疾病 (CVDs) 是全球死亡率的主要原因，在世界范围内观察到其患病率稳步上升。了解导致 CVD 发病机制的信号通路中涉及的分子机制代表了开发精确和靶向治疗的一个显著和有利的途径。CVDs 研究的一个最新进展是发现长非编码 RNA (lncRNA)，现在人们已经认识到它们在几种病理生理过程的发生和发展中起着至关重要的作用。lncRNA 在各种 CVD 背景下表现出不同的表达模式，为它们作为生物标志物和治疗干预靶点的应用提供了重要机会。在已鉴定的各种 lncRNA 中，HOX 反义基因间 RNA (HOTAIR) 作为信号分子，在心血管疾病的发病机制中对危险因素具有重要意义。已经观察到 HOTAIR 在血液中循环，并在许多疾病的转录途径中具有重要的表观遗传调控功能。最近的研究表明，HOTAIR 作为 CVDs 的检测和治疗标志物具有一定的应用前景。然而，关于 HOTAIR 在 CVDs 中的作用的研究仍处于早期阶段。本研究的目的是全面概述分析 HOTAIR 在控制 CVDs 病理生理过程中的分子机制及其可能的治疗用途方面的最新进展。
