Yazd Cardiovascular Research Center, Non-communicable Diseases Research Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Mciences, Birjand, Iran.
Int J Biol Macromol. 2023 Jan 15;225:1049-1071. doi: 10.1016/j.ijbiomac.2022.11.167. Epub 2022 Nov 19.
Cardiovascular diseases (CVDs) are a group of disorders with major global health consequences. The prevalence of CVDs continues to grow due to population-aging and lifestyle modifications. Non-coding RNAs (ncRNAs) as key regulators of cell signaling pathways have gained attention in the occurrence and development of CVDs. Exosomal-lncRNAs (exos-lncRNAs) are emerging biomarkers due to their high sensitivity and specificity, stability, accuracy and accessibility in the biological fluids. Recently, circulatory and exos-based-lncRNAs are emerging and novel bio-tools in various pathogenic conditions. It is worth mentioning that dysregulation of these molecules has been found in different types of CVDs. In this regard, we aimed to discuss the knowledge gaps and suggest research priorities regarding circulatory and exos-lncRNAs as novel bio-tools and therapeutic targets for CVDs.
心血管疾病（CVDs）是一组具有重大全球健康后果的疾病。由于人口老龄化和生活方式的改变，CVD 的患病率持续上升。非编码 RNA（ncRNA）作为细胞信号通路的关键调节因子，在 CVD 的发生和发展中受到关注。外泌体长非编码 RNA（exos-lncRNA）因其在生物体液中具有高灵敏度、特异性、稳定性、准确性和可及性，作为新兴的生物标志物而受到关注。最近，循环和基于外泌体的 lncRNA 在各种致病条件下成为新兴的和新颖的生物工具。值得一提的是，这些分子的失调已在不同类型的 CVD 中被发现。在这方面，我们旨在讨论循环和外泌体 lncRNA 作为 CVD 的新型生物工具和治疗靶点的知识空白，并提出研究重点。
