游离脂肪酸对脂质体对咪唑类抗真菌药物敏感性的影响。
Effect of free fatty acids on liposome susceptibility to imidazole antifungals.
作者信息
Sud I J, Chou D L, Feingold D S
出版信息
Antimicrob Agents Chemother. 1979 Nov;16(5):660-3. doi: 10.1128/AAC.16.5.660.
Abstract
The presence of free fatty acids in liposome model membranes sensitizes these membranes to the action of the imidazole antifungals, clotrimazole, micronazole, and sulconazole. Unsaturation of the fatty acids is an important variable; the effect of linoleic and oleic acids is much greater than that of stearic acid. The imidazoles differ somewhat in action, with clotrimazole potency greatest both on membranes with and without fatty acids. Sulconazole has very little activity on membranes without fatty acids even at the highest concentrations tested. The data are discussed with reference to the susceptibility of various cells to the imidazoles and the specificity of imidazole action. A modification of the enzymatic method generally used for assay of marker glucose with liposome systems is also presented.
摘要
脂质体模型膜中游离脂肪酸的存在使这些膜对咪唑类抗真菌药（克霉唑、咪康唑和硫康唑）的作用敏感。脂肪酸的不饱和程度是一个重要变量；亚油酸和油酸的作用远大于硬脂酸。咪唑类药物的作用略有不同，克霉唑在有脂肪酸和无脂肪酸的膜上效力均最强。即使在测试的最高浓度下，硫康唑对无脂肪酸的膜也几乎没有活性。结合各种细胞对咪唑类药物的敏感性和咪唑类作用的特异性对数据进行了讨论。还介绍了一种对脂质体系统中通常用于测定标记葡萄糖的酶法的改进方法。
相似文献
1
Effect of free fatty acids on liposome susceptibility to imidazole antifungals.游离脂肪酸对脂质体对咪唑类抗真菌药物敏感性的影响。
Antimicrob Agents Chemother. 1979 Nov;16(5):660-3. doi: 10.1128/AAC.16.5.660.
2
Effect of fatty acyl group and sterol composition on sensitivity of lecithin liposomes to imidazole antimycotics.脂肪酰基和甾醇组成对卵磷脂脂质体对咪唑类抗真菌药敏感性的影响。
Antimicrob Agents Chemother. 1979 May;15(5):706-11. doi: 10.1128/AAC.15.5.706.
3
In vitro susceptibility profile of 200 recent clinical isolates of Candida spp. to topical antifungal treatments of vulvovaginal candidiasis, the imidazoles and nystatin agents.200株近期念珠菌属临床分离株对念珠菌性外阴阴道炎局部抗真菌治疗药物（咪唑类和制霉菌素类药物）的体外药敏谱。
J Mycol Med. 2014 Dec;24(4):303-7. doi: 10.1016/j.mycmed.2014.05.001. Epub 2014 Oct 23.
4
Arachidonic acid increases antifungal susceptibility of Candida albicans and Candida dubliniensis.花生四烯酸可增强白色念珠菌和都柏林念珠菌的抗真菌药敏性。
J Antimicrob Chemother. 2009 Jan;63(1):124-8. doi: 10.1093/jac/dkn446. Epub 2008 Oct 29.
5
Antagonistic action of lipid components of membranes from Candida albicans and various other lipids on two imidazole antimycotics, clotrimazole and miconazole.白色念珠菌及其他多种脂质的膜脂质成分对两种咪唑类抗真菌药克霉唑和咪康唑的拮抗作用。
Antimicrob Agents Chemother. 1977 Jul;12(1):16-25. doi: 10.1128/AAC.12.1.16.
6
Inhibition of sterol biosynthesis in Candida albicans by imidazole-containing antifungals.含咪唑抗真菌药物对白色念珠菌中甾醇生物合成的抑制作用。
J Gen Microbiol. 1980 Mar;117(1):253-5. doi: 10.1099/00221287-117-1-253.
7
Antifungal relative inhibition factors: BAY l-9139, bifonazole, butoconazole, isoconazole, itraconazole (R 51211), oxiconazole, Ro 14-4767/002, sulconazole, terconazole and vibunazole (BAY n-7133) compared in vitro with nine established antifungal agents.抗真菌相对抑制因子：将BAY l-9139、联苯苄唑、布康唑、异康唑、伊曲康唑（R 51211）、奥昔康唑、Ro 14-4767/002、舒康唑、特康唑和维邦唑（BAY n-7133）与九种已确立的抗真菌药物进行体外比较。
J Antimicrob Chemother. 1984 Aug;14(2):105-14. doi: 10.1093/jac/14.2.105.
8
Suppression of ATP in Candida albicans by imidazole and derivative antifungal agents.咪唑及衍生物抗真菌剂对白色念珠菌中三磷酸腺苷的抑制作用。
Sabouraudia. 1985 Dec;23(6):415-24.
9
Effect of antifungal agents on lipid biosynthesis and membrane integrity in Candida albicans.抗真菌剂对白色念珠菌脂质生物合成及膜完整性的影响
Antimicrob Agents Chemother. 1987 Jan;31(1):46-51. doi: 10.1128/AAC.31.1.46.
10
In vitro activity of cloconazole, sulconazole, butoconazole, isoconazole, fenticonazole, and five other antifungal agents against clinical isolates of Candida albicans and Candida spp.氯康唑、舒康唑、布康唑、异康唑、芬替康唑及其他五种抗真菌剂对白色念珠菌和念珠菌属临床分离株的体外活性
Mycopathologia. 1992 Apr;118(1):15-21. doi: 10.1007/BF00472565.
引用本文的文献
1
The promising anti-virulence activity of candesartan, domperidone, and miconazole on Staphylococcus aureus.坎地沙坦、多潘立酮和咪康唑对金黄色葡萄球菌具有潜在的抗毒活性。
Braz J Microbiol. 2022 Mar;53(1):1-18. doi: 10.1007/s42770-021-00655-4. Epub 2021 Nov 13.
2
Preserving cultural heritage: Analyzing the antifungal potential of ionic liquids tested in paper restoration.保护文化遗产：分析在纸张修复中测试的离子液体的抗真菌潜力。
PLoS One. 2019 Sep 17;14(9):e0219650. doi: 10.1371/journal.pone.0219650. eCollection 2019.
3
Anti-Candida Activity of New Azole Derivatives Alone and in Combination with Fluconazole.新型唑类衍生物单独及与氟康唑联合使用时的抗念珠菌活性
Mycopathologia. 2015 Oct;180(3-4):203-7. doi: 10.1007/s11046-015-9899-9. Epub 2015 May 15.
4
Discovery of new imidazole derivatives containing the 2,4-dienone motif with broad-spectrum antifungal and antibacterial activity.发现含2,4-二烯酮基序且具有广谱抗真菌和抗菌活性的新型咪唑衍生物。
Molecules. 2014 Sep 29;19(10):15653-72. doi: 10.3390/molecules191015653.
5
Increase in colony-forming units of Candida albicans after treatment with polyene antibiotics.用多烯抗生素治疗后白色念珠菌菌落形成单位增加。
Antimicrob Agents Chemother. 1981 Jan;19(1):199-200. doi: 10.1128/AAC.19.1.199.
6
Growth phase in relation to ketoconazole and miconazole susceptibilities of Candida albicans.白色念珠菌生长阶段与酮康唑和咪康唑敏感性的关系
Antimicrob Agents Chemother. 1984 Mar;25(3):316-8. doi: 10.1128/AAC.25.3.316.
7
Action of antifungal imidazoles on Staphylococcus aureus.抗真菌咪唑类药物对金黄色葡萄球菌的作用。
Antimicrob Agents Chemother. 1982 Sep;22(3):470-4. doi: 10.1128/AAC.22.3.470.
8
Heterogeneity of action of mechanisms among antimycotic imidazoles.抗真菌咪唑类药物作用机制的异质性。
Antimicrob Agents Chemother. 1981 Jul;20(1):71-4. doi: 10.1128/AAC.20.1.71.
9
Sulconazole. A review of its antimicrobial activity and therapeutic use in superficial dermatomycoses.舒康唑。对其在浅表皮肤真菌病中的抗菌活性及治疗用途的综述。
Drugs. 1988 Feb;35(2):143-53. doi: 10.2165/00003495-198835020-00004.
10
Requirement for nonprotonated drug molecules in the direct lethal action of miconazole against Candida albicans.
Mycopathologia. 1988 Aug;103(2):91-4. doi: 10.1007/BF00441264.
本文引用的文献
1
Studies on the mechanism of action of miconazole: effect of miconazole on respiration and cell permeability of Candida albicans.咪康唑作用机制的研究：咪康唑对白色念珠菌呼吸及细胞通透性的影响
Antimicrob Agents Chemother. 1974 Apr;5(4):420-5. doi: 10.1128/AAC.5.4.420.
2
CHROMATOGRAPHICALLY HOMOGENEOUS LECITHIN FROM EGG PHOSPHOLIPIDS.源自鸡蛋磷脂的色谱纯卵磷脂
J Am Oil Chem Soc. 1965 Jan;42:53-6. doi: 10.1007/BF02558256.
3
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
4
Effect of cholesterol incorporation on the sensitivity liposomes to the polyene antibiotic, filipin.胆固醇掺入对脂质体对多烯抗生素制霉菌素敏感性的影响。
Biochim Biophys Acta. 1968 Jan 10;152(1):174-85. doi: 10.1016/0005-2760(68)90019-2.
5
Polyene antibiotic action on lecithin liposomes: effect of cholesterol and fatty acyl chains.多烯抗生素对卵磷脂脂质体的作用：胆固醇和脂肪酰链的影响
Biochem Biophys Res Commun. 1973 Apr 16;51(4):972-8. doi: 10.1016/0006-291x(73)90022-3.
6
Mode of action of clotrimazole.
Sabouraudia. 1973 Jul;11(2):158-66. doi: 10.1080/00362177385190321.
7
Effect of fatty acyl group and sterol composition on sensitivity of lecithin liposomes to imidazole antimycotics.脂肪酰基和甾醇组成对卵磷脂脂质体对咪唑类抗真菌药敏感性的影响。
Antimicrob Agents Chemother. 1979 May;15(5):706-11. doi: 10.1128/AAC.15.5.706.
8
Target substances of some antifungal agents in the cell membrane.一些抗真菌药物作用于细胞膜的靶物质。
Antimicrob Agents Chemother. 1978 Mar;13(3):454-9. doi: 10.1128/AAC.13.3.454.
9
Protection by unsaturated lecithin against the imidazole antimycotics, clotrimazole and miconazole.不饱和卵磷脂对咪唑类抗真菌药克霉唑和咪康唑的保护作用。
Antimicrob Agents Chemother. 1978 Mar;13(3):423-6. doi: 10.1128/AAC.13.3.423.
Zotero 插件