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发酵大豆食品对环磷酰胺处理的免疫抑制大鼠的免疫增强作用。

Immune-enhancing effect of fermented soybean food, on cyclophosphamide-treated immunosuppressed rat.

作者信息

Lee Hak Yong, Park Young Mi, Shin Dong Yeop, Hwang Hai Min, Jeong Han Na, Park Hyo Yeon, Yang Hee-Jong, Ha Gwang Su, Ryu Myeong Seon, Seo Ji Won, Jeong Do-Youn, Bae Jun Sang, Kim Byeong Soo, Kim Jae Gon

机构信息

INVIVO Co. Ltd., 121, Deahak-ro, Nonsan, Chungnam, 32992, Republic of Korea.

Department of Pathology, College of Korean Medicine, Wonkwang University, Iksan, Republic of Korea.

出版信息

Heliyon. 2024 Sep 14;10(18):e37845. doi: 10.1016/j.heliyon.2024.e37845. eCollection 2024 Sep 30.

DOI:10.1016/j.heliyon.2024.e37845
PMID:39328544
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11425096/
Abstract

Cheonggukjang () is a traditional food, made by the fermentation of beans, and it has different recipes for different regions in Korea. However, it has anti-inflammatory, anti-cancer, and anti-obesity effects, and is known to affect changes in the intestinal microbiota. In this study, we investigated the immune-enhancing effects of four type s (one commercial and three transitional s). In the cyclophosphamide (CP)-treated immunosuppressed rat, oral administration of s for 4 weeks was used to investigate weight of body and immune organ, change of microbiota, blood and serum parameters, inflammation pathways (MAPKs and NFκB) and histology of spleen. It showed an immunity-enhancing effect through increase Bacteroidetes in gut, the recovery of complete blood count, levels of cytokines and IgG, activation of inflammatory pathways, and histology of spleen. In conclusion, these results show that the intake of a commercial brand CGJ, and traditional CGJs can maintain or promote the body's immunity.

摘要

清国酱（）是一种传统食品，由豆类发酵制成，在韩国不同地区有不同的制作方法。然而，它具有抗炎、抗癌和抗肥胖作用，并且已知会影响肠道微生物群的变化。在本研究中，我们调查了四种类型（一种市售型和三种传统型）的免疫增强作用。在环磷酰胺（CP）处理的免疫抑制大鼠中，口服给予清国酱4周，以研究体重和免疫器官、微生物群变化、血液和血清参数、炎症途径（丝裂原活化蛋白激酶和核因子κB）以及脾脏组织学。它通过增加肠道中的拟杆菌、恢复全血细胞计数、细胞因子和免疫球蛋白G水平、激活炎症途径以及脾脏组织学而显示出免疫增强作用。总之，这些结果表明，摄入市售品牌的清国酱和传统清国酱可以维持或促进身体的免疫力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/45bf0cabc588/mmcfigs2.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/6e1fd4291308/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/4008b4038650/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/f8547ec12f78/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/4504bb2a081d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/e46b0f7ca9d4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/792df4b9c430/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/45bf0cabc588/mmcfigs2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/9a1ab40ab547/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/3a2b7eb0a15b/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/6e1fd4291308/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/4008b4038650/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/f8547ec12f78/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/4504bb2a081d/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/e46b0f7ca9d4/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/792df4b9c430/mmcfigs1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd4e/11425096/45bf0cabc588/mmcfigs2.jpg

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本文引用的文献

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Heliyon. 2024 Mar 8;10(6):e27383. doi: 10.1016/j.heliyon.2024.e27383. eCollection 2024 Mar 30.
2
Editorial: The gut-skin-brain axis in human health and disease.社论：人类健康与疾病中的肠-皮肤-脑轴
Front Nutr. 2023 Feb 16;10:1155614. doi: 10.3389/fnut.2023.1155614. eCollection 2023.
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Korean Red Ginseng modulates immune function by upregulating CD4CD8 T cells and NK cell activities on porcine.
韩国红参通过上调猪的CD4CD8 T细胞和NK细胞活性来调节免疫功能。
J Ginseng Res. 2023 Jan;47(1):155-158. doi: 10.1016/j.jgr.2022.10.002. Epub 2022 Oct 18.
4
Fermented natural product targeting gut microbiota regulate immunity and anti-inflammatory activity: A possible way to prevent COVID-19 in daily diet.针对肠道微生物群的发酵天然产物调节免疫和抗炎活性：日常饮食中预防新冠肺炎的一种可能途径。
J Funct Foods. 2022 Oct;97:105229. doi: 10.1016/j.jff.2022.105229. Epub 2022 Aug 22.
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Fermented Soy Products and Their Potential Health Benefits: A Review.发酵豆制品及其潜在的健康益处：综述
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