Helou Maroun, Al Irr Nael
General Practice, Faculty of Medicine and Health Science, Ramallah, PSE.
Internal Medicine, Palestine Medical Complex, Ramallah, PSE.
Cureus. 2024 Aug 28;16(8):e68044. doi: 10.7759/cureus.68044. eCollection 2024 Aug.
Pyoderma gangrenosum (PG) is a rare ulcerative skin condition. Familial Mediterranean fever (FMF) and Behçet's disease (BD) are autoinflammatory disorders common in Mediterranean populations. The coexistence of FMF and BD is unusual, and the presence of PG alongside both is even rarer. We present a case of a 51-year-old male diagnosed with both BD and FMF who developed PG during treatment. His PG lesion was managed with a tailored regimen that included topical hydrocortisone acetate with fusidic acid, colchicine, topical tacrolimus, oral prednisone, and intravenous infliximab, which led to the successful healing of the PG lesion. This case underscores the need for specialized approaches to manage overlapping autoinflammatory conditions.
坏疽性脓皮病（PG）是一种罕见的溃疡性皮肤病。家族性地中海热（FMF）和白塞病（BD）是在地中海人群中常见的自身炎症性疾病。FMF和BD同时存在的情况并不常见，而PG与两者同时出现则更为罕见。我们报告一例51岁男性病例，该患者被诊断患有BD和FMF，在治疗期间出现了PG。他的PG皮损采用了一种定制的治疗方案进行处理，该方案包括外用醋酸氢化可的松联合夫西地酸、秋水仙碱、外用他克莫司、口服泼尼松以及静脉注射英夫利昔单抗，这使得PG皮损成功愈合。该病例强调了针对重叠性自身炎症性疾病采取专门治疗方法的必要性。
