单次口服头孢克洛治疗产青霉素酶淋病奈瑟菌感染。
Single oral dose of cefaclor for the treatment of infections with penicillinase-producing strains of Neisseria gonorrhoeae.
作者信息
Tupasi T E, Calubiran O V, Torres C A
出版信息
Br J Vener Dis. 1982 Jun;58(3):176-9. doi: 10.1136/sti.58.3.176.
Abstract
A single oral dose of 3 g cefaclor was effective in the treatment of uncomplicated gonococcal infection in women due to penicillinase-producing strains of Neisseria gonorrhoeae (PPNG). Cefaclor was equally active in vitro against both PPNG (MIC range, 0.01-1.0 microgram/ml) and non-PPNG strains (MIC range, 0.005-2.0 micrograms/ml). As empirical treatment cefaclor was effective in 53 of 57 (93%) patients compared with ampicillin, to which only 37 of 53 (69.8%) patients responded. This difference was attributed to the 40% incidence of PPNG in the patients studied; as expected, such patients responded poorly to ampicillin.
摘要
单次口服3克头孢克洛对治疗女性因产青霉素酶淋病奈瑟菌（PPNG）引起的单纯性淋菌感染有效。头孢克洛在体外对PPNG（MIC范围为0.01 - 1.0微克/毫升）和非PPNG菌株（MIC范围为0.005 - 2.0微克/毫升）均有同等活性。作为经验性治疗，与氨苄西林相比，头孢克洛在57例患者中的53例（93%）有效，而氨苄西林在53例患者中仅37例（69.8%）有反应。这种差异归因于所研究患者中PPNG的发生率为40%；正如预期的那样，这类患者对氨苄西林反应不佳。
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