Robert N. Butler Columbia Aging Center and Department of Environmental Health Sciences, Columbia University, New York, New York, USA.
Department of Geriatric Medicine, Radboud University Medical Center, Nijmegen, The Netherlands.
J Gerontol A Biol Sci Med Sci. 2024 Oct 1;79(10). doi: 10.1093/gerona/glae210.
It is becoming highly accepted that aging, age-related diseases, and geriatric healthcare can move forward if reductionist research is complemented by integrative research uniting knowledge on specific aging mechanisms, multiple biomedical, social, psychological, lifestyle, and environmental factors and their interactions. In this special issue, we present exciting papers that illustrate how complexity science theory and practice can be applied to aging research and provide a better understanding and quantification of healthy aging and vulnerability to disease. Recent insights on biomarkers, clocks of aging, frailty, and resilience are covered and studied in interaction with a dynamic multiscale perspective. The editorial and closing viewpoint guide you through basic principles of gerontological complexity science and shed light on new research horizons, including innovative systems-based interventions.
越来越多的人认为，如果能够将特定衰老机制、多种生物医学、社会、心理、生活方式和环境因素及其相互作用的知识整合到统一的研究中，辅以还原论研究，衰老、与年龄相关的疾病和老年保健就能取得进展。在本期特刊中，我们呈现了一些令人兴奋的论文，这些论文说明了复杂性科学理论和实践如何应用于衰老研究，并提供了对健康衰老和疾病易感性的更好理解和量化。涵盖了关于生物标志物、衰老时钟、脆弱性和恢复力的最新见解，并结合动态多尺度视角进行了研究。社论和结束语观点为您介绍了老年复杂性科学的基本原则，并探讨了新的研究前沿，包括创新的基于系统的干预措施。
