津巴布韦农村母婴二元组中组织血型抗原状态与婴儿口服轮状病毒疫苗免疫原性之间的关联

Associations Between Histo-blood Group Antigen Status in Mother-Infant Dyads and Infant Oral Rotavirus Vaccine Immunogenicity in Rural Zimbabwe.

作者信息

Pun Joshua, Evans Ceri, Chasekwa Bernard, Church James A, Gough Ethan, Mutasa Kuda, Rukobo Sandra, Govha Margaret, Mushayanembwa Patience, Majo Florence D, Tavengwa Naume V, Humphrey Jean H, Kirkpatrick Beth D, Kosek Margaret, Ntozini Robert, Prendergast Andrew J

机构信息

Centre for Genomics and Child Health, Blizard Institute, Queen Mary University of London, United Kingdom.

Zvitambo Institute for Maternal and Child Health Research, Harare, Zimbabwe.

出版信息

J Infect Dis. 2025 Feb 4;231(1):e225-e233. doi: 10.1093/infdis/jiae456.

DOI:10.1093/infdis/jiae456

PMID:39352457

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11793023/

Abstract

BACKGROUND

Histo-blood group antigen (HBGA) phenotypes may contribute to poor oral rotavirus vaccine (RVV) immunogenicity, since rotavirus binds intestinal epithelial HBGA glycans, while maternal HBGA status shapes breastmilk composition, which influences the composition of the infant microbiome. We investigated associations between maternal/infant HBGA phenotypes and RVV immunogenicity in rural Zimbabwe.

METHODS

We undertook salivary FUT2/FUT3 phenotyping in mother-infant pairs. Serum anti-rotavirus immunoglobulin A was measured by enzyme-linked immunosorbent assay. We explored adjusted associations between FUT2/FUT3 status and RVV seroconversion (primary outcome, n = 322) and seropositivity and geometric mean titer (secondary outcomes, n = 776).

RESULTS

Infants of FUT2- or FUT3-positive women were less likely to seroconvert post-RVV than infants of FUT2- or FUT3-negative women (FUT2 positive [20.1%] vs FUT2 negative [27.5%]: adjusted relative risk [aRR], 0.47; 95% CI, .26-.82; P = .008; FUT3 positive [18.1%] vs FUT3 negative [30.0%]: aRR, 0.45; 95% CI, .25-.78; P = .005). When compared with FUT2-positive infants with FUT2-positive mothers, FUT2-positive infants with FUT2-negative mothers were twice as likely to seroconvert (36.8% vs 21.9%; aRR, 2.12; 95% CI, 1.23-3.63; P = .006). When compared with FUT3-positive infants with FUT3-positive mothers, FUT3-positive infants with FUT3-negative mothers were 3 times as likely to seroconvert (48.3% vs 18.2%; aRR, 2.99; 95% CI, 1.82-4.90; P < .001).

CONCLUSIONS

Maternal and infant FUT2 and FUT3 status influences infant RVV immunogenicity.

摘要

背景

组织血型抗原（HBGA）表型可能导致口服轮状病毒疫苗（RVV）免疫原性不佳，因为轮状病毒可结合肠道上皮HBGA聚糖，而母体HBGA状态会影响母乳成分，进而影响婴儿微生物群的组成。我们在津巴布韦农村地区调查了母体/婴儿HBGA表型与RVV免疫原性之间的关联。

方法

我们对母婴对进行了唾液FUT2/FUT3表型分析。通过酶联免疫吸附测定法检测血清抗轮状病毒免疫球蛋白A。我们探讨了FUT2/FUT3状态与RVV血清转化（主要结局，n = 322）以及血清阳性和几何平均滴度（次要结局，n = 776）之间的校正关联。

结果

FUT2或FUT3阳性女性的婴儿在接种RVV后血清转化的可能性低于FUT2或FUT3阴性女性的婴儿（FUT2阳性[20.1%] vs FUT2阴性[27.5%]：校正相对风险[aRR]，0.47；95% CI，0.26 - 0.82；P = 0.008；FUT3阳性[18.1%] vs FUT3阴性[30.0%]：aRR，0.45；95% CI，0.25 - 0.78；P = 0.005）。与母亲为FUT2阳性的FUT2阳性婴儿相比，母亲为FUT2阴性的FUT2阳性婴儿血清转化的可能性高出两倍（36.8% vs 21.9%；aRR，2.12；95% CI，1.23 - 3.63；P = 0.006）。与母亲为FUT3阳性的FUT3阳性婴儿相比，母亲为FUT3阴性的FUT3阳性婴儿血清转化的可能性高出三倍（48.3% vs 18.2%；aRR，2.99；95% CI，1.82 - 4.90；P < 0.001）。