African Field Epidemiology Network, Abuja, Nigeria.
Ahmadu Bello University Zaria, Kaduna State, Nigeria.
Pan Afr Med J. 2024 Sep 2;49:1. doi: 10.11604/pamj.2024.49.1.44172. eCollection 2024.
rubella poses a significant public health threat, particularly in developing countries, where congenital rubella remains a preventable concern. This cross-sectional study examined rubella seroprevalence among children aged 10 and under from May to September 2016 in Jos, Nigeria.
using a multistage sampling method, eligible participants who had not been vaccinated against the rubella virus and consented to participate in the study were recruited across schools in the city. Rubella-specific IgG and IgM antibodies were detected from eluted serum collected from the participants using the enzyme-linked immunosorbent assay (ELISA). Data analysis and visualization was done using the R software version 4.3.1.
of the 405 participants investigated in this study, 336 (82.96%) tested positive for rubella IgG, while 9 (2.22%) tested positive for rubella IgM. Factors such as age ≥ 5 years and lack of Western education showed significant associations with rubella seropositivity.
this study highlights the seroprevalence of rubella IgG and IgM antibodies among children aged 10 and under in Jos, Nigeria. The significant associations between rubella seropositivity and factors such as age ≥ 5 years and lack of Western education underscore the necessity for an effective rubella vaccination program to prevent congenital rubella syndrome (CRS).
风疹对公共卫生构成重大威胁，特别是在发展中国家，先天性风疹仍然是一个可预防的问题。本横断面研究于 2016 年 5 月至 9 月在尼日利亚乔斯检查了 10 岁及以下儿童的风疹血清流行率。
采用多阶段抽样方法，在该市的学校中招募了未接种风疹病毒疫苗且同意参加研究的合格参与者。使用酶联免疫吸附试验（ELISA）从参与者洗脱的血清中检测风疹特异性 IgG 和 IgM 抗体。数据分析和可视化使用 R 软件版本 4.3.1 完成。
在本研究中调查的 405 名参与者中，336 名（82.96%）对风疹 IgG 呈阳性，而 9 名（2.22%）对风疹 IgM 呈阳性。年龄≥5 岁和缺乏西方教育等因素与风疹血清阳性显著相关。
本研究强调了尼日利亚乔斯 10 岁及以下儿童风疹 IgG 和 IgM 抗体的血清流行率。风疹血清阳性与年龄≥5 岁和缺乏西方教育等因素之间的显著关联突出表明，需要实施有效的风疹疫苗接种计划以预防先天性风疹综合征（CRS）。
